SHIP limits immunoregulatory capacity in the T-cell compartment. - Wikidata - wikimedia - TriplyDB

SHIP limits immunoregulatory capacity in the T-cell compartment.

SHIP limits immunoregulatory capacity in the T-cell compartment.

http://www.wikidata.org/entity/Q37143643

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A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells.Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function Discovery and development of small molecule SHIP phosphatase modulators.SHIPi Enhances Autologous and Allogeneic Hematolymphoid Stem Cell Transplantation.Preparation of myeloid derived suppressor cells (MDSC) from naive and pancreatic tumor-bearing mice using flow cytometry and automated magnetic activated cell sorting (AutoMACS).Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3.Mouse natural killer cell development and maturation are differentially regulated by SHIP-1.Regulatory myeloid suppressor cells in health and disease Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.Inhibitor and activator: dual functions for SHIP in immunity and cancer.Role of inositol poly-phosphatases and their targets in T cell biology.Signals and pathways controlling regulatory T cells.Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target.Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP.Role of SHIP1 in Invariant NKT Cell Development and Functions.SHIP1 intrinsically regulates NK cell signaling and education, resulting in tolerance of an MHC class I-mismatched bone marrow graft in mice Impaired T-cell survival promotes mucosal inflammatory disease in SHIP1-deficient mice.Does the PI3K pathway promote or antagonize regulatory T cell development and function?SHIP deficiency causes Crohn's disease-like ileitis.Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system: success, disappointment, and new opportunities.SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity.Expression of microRNA-155 in inflammatory cells modulates liver injury.KMT1E-mediated chromatin modifications at the FcγRIIb promoter regulate thymocyte development.SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn's Disease and Peripheral T Cell Reduction.Myeloid cell-specific expression of Ship1 regulates IL-12 production and immunity to helminth infection

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SHIP limits immunoregulatory capacity in the T-cell compartment.

http://www.wikidata.org/entity/Q37143643

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 09 January 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

SHIP limits immunoregulatory capacity in the T-cell compartment.

@en

SHIP limits immunoregulatory capacity in the T-cell compartment.

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type

label

SHIP limits immunoregulatory capacity in the T-cell compartment.

@en

SHIP limits immunoregulatory capacity in the T-cell compartment.

@nl

prefLabel

SHIP limits immunoregulatory capacity in the T-cell compartment.

@en

SHIP limits immunoregulatory capacity in the T-cell compartment.

@nl

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BLOOD-2008-09-181164

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SHIP limits immunoregulatory capacity in the T-cell compartment

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Cam-Tien Le

http://www.w3.org/2001/XMLSchema#string

Daniela Wood

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Diana Stauch

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Erin Lund

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Katja Kotsch

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Kim H T Paraiso

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Michelle M Collazo

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Robert W Engelman

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P2860

Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion

The physiological role of regulatory T cells in the prevention of autoimmunity: the function of the thymus in the generation of the regulatory T cell subset.

Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease.

PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs

T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses.

Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation.

Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone.

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2934-2944

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scholarly article

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10.1182/BLOOD-2008-09-181164

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13

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William G. Kerr

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2009-01-09T00:00:00Z

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23770931

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19136659

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2662640

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