Predicting pharmacokinetics of drugs using physiologically based modeling--application to food effects
about
The use of modeling tools to drive efficient oral product designTranslating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption.Utility of physiologically based absorption modeling in implementing Quality by Design in drug developmentCase studies for practical food effect assessments across BCS/BDDCS class compounds using in silico, in vitro, and preclinical in vivo data.Utility of physiologically based modeling and preclinical in vitro/in vivo data to mitigate positive food effect in a BCS class 2 compound.Characterisation of mixing in the proximal duodenum of the rat during longitudinal contractions and comparison with a fluid mechanical model based on spatiotemporal motility dataIn vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases.A physiologically based pharmacokinetic model of the minipig: data compilation and model implementation.Application of Physiologically Based Absorption Modeling to Characterize the Pharmacokinetic Profiles of Oral Extended Release Methylphenidate Products in AdultsMechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport.Summary of the National Institute of Child Health and Human Development-best pharmaceuticals for Children Act Pediatric Formulation Initiatives Workshop-Pediatric Biopharmaceutics Classification System Working Group.Physiologically based pharmacokinetic models: integration of in silico approaches with micro cell culture analogues.Application of physiologically based absorption modeling to formulation development of a low solubility, low permeability weak base: mechanistic investigation of food effect.From bench to humans: formulation development of a poorly water soluble drug to mitigate food effectThe evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune diseaseAn update on computational oral absorption simulation.Coupling biorelevant dissolution methods with physiologically based pharmacokinetic modelling to forecast in-vivo performance of solid oral dosage forms.A case study of in silico modelling of ciprofloxacin hydrochloride/metallic compound interactionsPhysiologically based pharmacokinetic models of small molecules and therapeutic antibodies: a mini-review on fundamental concepts and applications.Establishment and Characterization of Immortalized Minipig Neural Stem Cell Line.Drug interactions with aprepitant or fosaprepitant: Review of literature and implications for clinical practice.Mechanistic prediction of food effects for Compound A tablet using PBPK model.Lipid-associated oral delivery: Mechanisms and analysis of oral absorption enhancement.An introduction to physiologically-based pharmacokinetic models.Examining Small Intestinal Transit Time as a Function of Age: Is There Evidence to Support Age-Dependent Differences among Children?Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin.Food Effect in Humans: Predicting the Risk Through In Vitro Dissolution and In Vivo Pharmacokinetic Models.Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development.Incorporation of physiologically based pharmacokinetic modeling in the evaluation of solubility requirements for the salt selection process: a case study using phenytoin.Use of preclinical dog studies and absorption modeling to facilitate late stage formulation bridging for a BCS II drug candidate.Application of Absorption Modeling in Rational Design of Drug Product Under Quality-by-Design Paradigm.Mass spectrometry-based quantification of CYP enzymes to establish in vitro/in vivo scaling factors for intestinal and hepatic metabolism in beagle dog.Nilotinib preclinical pharmacokinetics and practical application toward clinical projections of oral absorption and systemic availability.Combining "Bottom-up" and "Top-down" Approaches to Assess the Impact of Food and Gastric pH on Pictilisib (GDC-0941) Pharmacokinetics.Physiologically based pharmacokinetic modelling to predict single- and multiple-dose human pharmacokinetics of bitopertin.Choroid plexus papilloma-A case highlighting the challenges of extrapolating pediatric chemotherapy regimens to adult populations.A mechanism-based pharmacokinetic model of fenofibrate for explaining increased drug absorption after food consumption.Predictive Performance of Physiologically Based Pharmacokinetic Models for the Effect of Food on Oral Drug Absorption: Current Status.Monitoring of erlotinib in pancreatic cancer patients during long-time administration and comparison to a physiologically based pharmacokinetic model.Food Effect on Oral Bioavailability: Old and New Questions.
P2860
Q26824320-C6350D0B-D324-49CB-85D1-08BEF4FD5DD8Q27313187-4CBDF387-7996-4B9F-981A-5F36F92E7186Q30498061-1D5095B0-4003-4B1E-8098-5374C091B22AQ30576914-D49EC301-6491-41F5-8133-B285F4A2D26CQ30662113-0BFD0E0C-A59F-452A-A913-703F7D037F97Q30804633-D47BF3B7-FEF5-49A9-B308-66A12156AFCCQ33811937-3536F0C6-EF30-4662-9F3C-0D99F53A88A0Q34487999-D0B65B4E-5B71-4665-8A44-82098A8C4A93Q36159334-AA9AFC8B-C094-497C-BE56-10E89B163C12Q36303746-F8BC9A35-81A8-486A-B543-35323A04B56CQ36501845-49310B98-5250-4E49-AA92-2A6362F4B49AQ37665888-ED2A3067-CC12-4157-931A-1EC1A8A8DDEEQ37671837-09439D86-D1BD-4D73-B018-05908D4F7EC6Q37671854-404DF413-96EE-4BFB-BB16-7276BE28D558Q37818144-37A1BF33-796F-4976-B633-1ED035CA6260Q37937047-89BE14BD-F35E-4E47-9654-E32596DA3580Q38112181-3C32664A-7AC9-4396-835E-AF6AD91119C2Q38555068-1A20B9C8-B117-4582-87E3-51973D43938BQ38605894-C5BFB246-F1DA-4740-B70C-368E4773E9CBQ38751883-55C85529-B26D-4F38-8C70-F6E7B5F92FD1Q38752456-6AD3472C-7ECB-4091-A01B-5AC696E183FFQ38848902-E88C07B9-FAE0-4B9B-B8CF-39B93211081BQ38926514-F8831227-7C66-4AAE-AA33-5A1EA623B59AQ38934455-44FD56A0-4994-408E-A85F-EF39F9A55270Q39920399-ED9191CA-A659-496F-904C-00BE65118176Q40272327-08EF4BA4-5B16-4044-B6E3-9330754BA075Q40987176-F682B6F1-9F55-48A4-BC07-15A61EA3B2CFQ41768726-16A60190-CE0A-4276-A168-FE6F65D8D6A6Q41820686-1195DA03-3818-4F33-A155-0B7CF9A452FCQ41904429-D38F6F7C-FF57-4F9F-AFF9-CB25DE0BF109Q41986678-314B4B18-072C-4648-B216-1B435A7C8AB7Q44958687-6D454418-C8D2-442D-A942-DD9EF490707BQ45805301-27FC09BB-488C-4734-B2C4-099F46FA0059Q45977183-8AF4F1F2-000B-4B27-96FD-8CC6B9CFA00DQ46379587-85DF07C6-8C03-4803-858F-B77DF13F11BBQ46860950-83F67F3A-CD5B-4C24-A0D3-9F98E0C43CEEQ49165101-3A7C6BE1-DF01-49F0-ACC2-C46250AAD076Q49716638-C2950807-7BF4-4436-93E3-22F1A87F52B6Q49909297-E5799A93-3E35-4BE5-B96E-AEB68D84E1ABQ53370868-603D5AC4-3253-41EA-95E1-F7AEEA7AC50E
P2860
Predicting pharmacokinetics of drugs using physiologically based modeling--application to food effects
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 29 January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Predicting pharmacokinetics of ...... g--application to food effects
@en
Predicting pharmacokinetics of ...... --application to food effects.
@nl
type
label
Predicting pharmacokinetics of ...... g--application to food effects
@en
Predicting pharmacokinetics of ...... --application to food effects.
@nl
prefLabel
Predicting pharmacokinetics of ...... g--application to food effects
@en
Predicting pharmacokinetics of ...... --application to food effects.
@nl
P2093
P2860
P1433
P1476
Predicting pharmacokinetics of ...... g--application to food effects
@en
P2093
G Fraczkiewicz
M B Bolger
V Lukacova
P2860
P2888
P356
10.1208/S12248-008-9079-7
P407
P577
2009-01-29T00:00:00Z
P5875
P6179
1035753001