A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin
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Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2Aflatoxin: a 50-year odyssey of mechanistic and translational toxicologyMechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseCovalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition ReactionsPotency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index.Low-Dose Dose-Response for In Vitro Nrf2-ARE Activation in Human HepG2 CellsAn exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) miceCDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cellsDNA Sequence Modulates Geometrical Isomerism of the trans-8,9- Dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)- 9-hydroxy Aflatoxin B1 AdductTricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agentsCDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and HumansPharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression.The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock ResponseThe cytoprotective role of the Keap1-Nrf2 pathway.Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.Synthesis of (13) C2 (15) N2 -labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([(13) C2 (15) N2 ]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method.HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway.Lactone metabolite common to the carcinogens dioxane, diethylene glycol, and N-nitrosomorpholine: aqueous chemistry and failure to mediate liver carcinogenesis in the F344 rat.C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases
P2860
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P2860
A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
A novel acetylenic tricyclic bis-
@nl
A novel acetylenic tricyclic b ...... nogenesis induced by aflatoxin
@en
type
label
A novel acetylenic tricyclic bis-
@nl
A novel acetylenic tricyclic b ...... nogenesis induced by aflatoxin
@en
prefLabel
A novel acetylenic tricyclic bis-
@nl
A novel acetylenic tricyclic b ...... nogenesis induced by aflatoxin
@en
P2093
P2860
P1433
P1476
A novel acetylenic tricyclic b ...... nogenesis induced by aflatoxin
@en
P2093
Bill D Roebuck
Charlotte R Williams
Chitra Sundararajan
Darlene B Royce
Gordon W Gribble
Hidenori Yoshizawa
John D Groopman
Karen J Baumgartner
Katherine K Stephenson
Mark M Yore
P2860
P304
P356
10.1158/0008-5472.CAN-08-1123
P407
P577
2008-08-01T00:00:00Z