mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
about
Advances in Autophagy Regulatory MechanismsInhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and BeyondRegulation of global and specific mRNA translation by the mTOR signaling pathwayTor forms a dimer through an N-terminal helical solenoid with a complex topology.Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor SpecificitySignaling, Regulation, and Specificity of the Type II p21-activated KinasesLa-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespanThe Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingGAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathwaysChemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins.Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulatorA C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagyTemporal and spatial regulation of translation in the mammalian oocyte via the mTOR-eIF4F pathwayThree distinct ribosome assemblies modulated by translation are the building blocks of polysomes.The role of target of rapamycin signaling networks in plant growth and metabolism.Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomasApplication of the [γ-32P] ATP kinase assay to study anabolic signaling in human skeletal musclemTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKKβ-mTORC1 axis to regulate renal cancer cell invasion.Selective anti-cancer agents as anti-aging drugsRapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis.Insulin granules. Insulin secretory granules control autophagy in pancreatic β cells.Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signalingMitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.Growing knowledge of the mTOR signaling network.Master Regulators in Plant Glucose Signaling NetworksThe PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer.mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.Endurance exercise induces REDD1 expression and transiently decreases mTORC1 signaling in rat skeletal muscle.mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells.Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling.The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.Relative specificity: all substrates are not created equal.Cucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity.Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates.Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo.Differential Reponses of Hematopoietic Stem and Progenitor Cells to mTOR Inhibition.AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis
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mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
@en
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin.
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type
label
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
@en
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin.
@nl
prefLabel
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
@en
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin.
@nl
P2093
P2860
P356
P1433
P1476
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
@en
P2093
Benjamin E Turk
Christopher L Cervantes
Daniel Lim
David M Sabatini
Hua Jane Lou
Kathleen Ottina
Michael B Yaffe
Michael E Pacold
Nathanael S Gray
Seong A Kang
P2860
P304
P356
10.1126/SCIENCE.1236566
P407
P577
2013-07-01T00:00:00Z