The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).
about
Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylationEssential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesisActivation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesRemote control of gene function by local translationTumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancerSleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress.Consolidation and translation regulationStructure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4GThe diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitorCotargeting MNK and MEK kinases induces the regression of NF1-mutant cancersMycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology.Suppression Of β-catenin Nuclear Translocation By CGP57380 Decelerates Poor Progression And Potentiates Radiation-Induced Apoptosis in Nasopharyngeal Carcinoma.Eukaryotic initiation factor 4F: a vulnerability of tumor cells.On the Diversification of the Translation Apparatus across EukaryotesTargeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73.Up-regulated microRNA499a by hepatitis B virus induced hepatocellular carcinogenesis via targeting MAPK6Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes.The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survivalCell-to-cell variability of alternative RNA splicing.Plant cap-binding complexes eukaryotic initiation factors eIF4F and eIFISO4F: molecular specificity of subunit binding.RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growthLight-regulated translational control of circadian behavior by eIF4E phosphorylation.4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors.Emerging therapeutics targeting mRNA translationInterleukin-10 inhibits lipopolysaccharide-induced tumor necrosis factor-α translation through a SHIP1-dependent pathway.Weighing up the possibilities: Controlling translation by ubiquitylation and sumoylation.Therapeutic interventions to disrupt the protein synthetic machinery in melanomaMnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.Contrasting roles of mitogen-activated protein kinases in cellular entry and replication of hepatitis C virus: MKNK1 facilitates cell entry.The unique Leishmania EIF4E4 N-terminus is a target for multiple phosphorylation events and participates in critical interactions required for translation initiation.MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct waysInhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors.Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and FunctionEssential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursorsCombined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activityCGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway.MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e.Mechanisms of translational regulation in synaptic plasticity.
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The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).
@en
The Mnks: MAP kinase-interacting kinases
@nl
type
label
The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).
@en
The Mnks: MAP kinase-interacting kinases
@nl
prefLabel
The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).
@en
The Mnks: MAP kinase-interacting kinases
@nl
P356
P1476
The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).
@en
P2093
Josep L Parra-Palau
Maria Buxade
P304
P356
10.2741/3086
P577
2008-05-01T00:00:00Z