PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival. - Wikidata - wikimedia - TriplyDB

PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival.

PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival.

http://www.wikidata.org/entity/Q37178227

about

Involvement of autophagy in ovarian cancer: a working hypothesis PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells The PEA-15 protein regulates autophagy via activation of JNK On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-catenin.Antagonism of tumoral prolactin receptor promotes autophagy-related cell death.Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.Classifying ten types of major cancers based on reverse phase protein array profiles.PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D MEK1/2 inhibitor selumetinib (AZD6244) inhibits growth of ovarian clear cell carcinoma in a PEA-15-dependent manner in a mouse xenograft model High ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patients Development of PEA-15 using a potent non-viral vector for therapeutic application in breast cancer.Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoter Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP.ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence.Active autophagy in the tumor microenvironment: A novel mechanism for cancer metastasis.Involvement of autophagy in cervical, endometrial and ovarian cancer.Shining light on cell death processes - a novel biosensor for necroptosis, a newly described cell death program.Baicalein Induces Beclin 1- and Extracellular Signal-Regulated Kinase-Dependent Autophagy in Ovarian Cancer Cells.Targetting PED/PEA-15 for diabetes treatment.Phosphoprotein enriched in diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib.Role of Hydroxysteroid Dehydrogenase-Like 2 (HSDL2) in Human Ovarian Cancer.Scutellarin induces apoptosis and autophagy in NSCLC cells through ERK1/2 and AKT Signaling Pathways in vitro and in vivo

P2860

Q21198790-18781E80-44FE-4280-91F6-481835C6CB1B Q24323230-003D0AA3-310E-46EC-A5EA-806E96196161 Q24618100-D8B74794-1484-4F2C-8526-E20DD80A11FD Q26799216-56EC2F87-CD06-4BC3-8B23-6C616329F75B Q30417536-71542FEB-C0D6-4620-AF65-82816AAEDE42 Q30523997-6A209828-C512-4ED4-9A8A-585CE7CC482F Q30579272-55C59E12-5698-4F8D-8962-D8074FDD94F4 Q33647052-FFCEBB2E-32B3-48C9-ACA6-0E85A5DC891D Q33743600-A19B6EFC-132E-483E-A526-E750B72E4676 Q34024181-EED7889C-5EB6-4B2F-8795-02F35F7E5C5D Q35590038-9693B5AC-054A-4EE2-ACE6-56726EA5F790 Q35809595-2B3123A9-AE47-4B67-9251-CA15778D06BE Q35872321-467A2E8B-F102-4E00-ADB2-7C915B53B756 Q36051484-78268EE2-F8AF-4C94-B783-0C69BEC2AC58 Q36063546-1C544748-FE58-42A1-AD4C-BC416F8D9EAC Q36235303-1752B3A2-2DAC-4DDF-9E02-481808AF50C2 Q36926900-7625EAA6-6821-4293-86BF-8BC7B778AB58 Q37618297-F9227AAA-EAF5-4E03-B91F-F3BC4810BF1A Q38082724-292F7637-A898-473E-80A4-56AB55A416BB Q38152325-91267E1C-5833-40F7-9AC4-7752671F9EC8 Q38175903-5CD43B4A-15C0-465B-87D0-4477FD868B3C Q38721686-13C49717-9C25-4D51-9752-0DAB3667C31A Q39232367-39CFA364-1121-4E3D-894E-E9DF338F17F4 Q43905855-6F99D80A-BBA9-4E26-B477-A5DC450D91B1 Q55452531-FA850F7A-C197-402A-9CAF-08AB4ABAE428 Q57116844-D86675FA-00E9-4696-88E7-2DF069E455A2

P2860

PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival.

http://www.wikidata.org/entity/Q37178227

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年学术文章

@wuu

2008年学术文章

@zh-cn

2008年学术文章

@zh-hans

2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

@zh

2008年學術文章

@zh-hant

name

PEA-15 induces autophagy in hu ...... th prolonged overall survival.

@en

PEA-15 induces autophagy in hu ...... th prolonged overall survival.

@nl

type

label

PEA-15 induces autophagy in hu ...... th prolonged overall survival.

@en

PEA-15 induces autophagy in hu ...... th prolonged overall survival.

@nl

prefLabel

PEA-15 induces autophagy in hu ...... th prolonged overall survival.

@en

PEA-15 induces autophagy in hu ...... th prolonged overall survival.

@nl

P1433

Q37178227-14E39491-FED4-4049-A81A-63DCA3C3CD1E

P1476

Q37178227-BD58C476-6795-44B1-BE83-5B6B32A2BF44

P2093

Q37178227-1AC9AA5A-A99D-4E64-823A-19151D883021

Q37178227-1B95F84D-A714-47C6-A62E-FA99B9BA7146

Q37178227-32F13EE6-C453-4F09-960E-991B88CC1C9B

Q37178227-4861BDEE-00FC-4285-89AD-66E94BAA6D30

Q37178227-5B15CB41-5651-4A93-A31A-C8358FE6BA7D

Q37178227-6BD29C99-22EA-4857-955F-E11ECC3E35F2

Q37178227-B604774B-2319-4A5A-A35D-28EF9ED7A42C

Q37178227-B6B4E93C-074A-4078-AF75-B733B59ED1F7

Q37178227-C20E1DD3-996E-4FB3-B730-F22FF8F80AB6

Q37178227-C6418526-D75D-47D7-8163-9E381347A9FC

P2860

Q37178227-07162677-9022-435D-AF70-EFE7B3AE1088

Q37178227-09F97543-6CC8-48E1-B335-E0D8A03FA106

Q37178227-0A1768A7-E2CB-45B8-852C-93609F17E866

Q37178227-0D1338A4-D307-4246-9CBF-0C97DF296385

Q37178227-0FF55AB2-A954-4F96-BD10-D6FF7EF0F059

Q37178227-1D0D0E4D-0E5C-4DBA-8D18-4AF2AF91A5AF

Q37178227-2333DABA-F643-48FE-91A0-E0AD21BF8CCC

Q37178227-287FFE7C-4636-4F5F-AD0C-FF398DD79697

Q37178227-2929F0D2-15BF-4C91-8073-CAB7B47929BD

Q37178227-2DA73BDA-25DF-4943-860E-E621ADDC9F9D

P304

Q37178227-158C9FBA-ABB3-4CC1-9081-F26F6AA708FF

P31

Q37178227-A523F1D4-E6DE-4F18-9E33-6579D4A97EF7

P356

Q37178227-205AB459-DABE-4D49-9CA9-3E55BD6DFCC7

P407

Q37178227-207618FB-CEA7-4A2B-8043-9DD30F5FA699

P433

Q37178227-F712BD37-DF82-4305-B72D-105DD7D73C23

P478

Q37178227-6C4A6E93-A014-4F8B-85CA-5E054DDD0F38

P577

Q37178227-042611A7-4D65-4EA8-A2FC-37977488016D

P698

Q37178227-B2B4A738-EE16-45A0-BB87-7340CB7F1F31

P921

Q37178227-0E063001-774D-46AC-AE6B-CCE4226F4D5F

Q37178227-DBEC8F16-3CEF-406F-A83F-CD6624272E9D

P932

Q37178227-B6083748-20E5-4EC6-8A0D-01ABD401292D

P356

0008-5472.CAN-08-2592

P1433

Cancer Research

P1476

PEA-15 induces autophagy in hu ...... th prolonged overall survival.

@en

P2093

Anna Kazansky

http://www.w3.org/2001/XMLSchema#string

Caimiao Wei

http://www.w3.org/2001/XMLSchema#string

Chandra Bartholomeusz

http://www.w3.org/2001/XMLSchema#string

Daniel Rosen

http://www.w3.org/2001/XMLSchema#string

Fumiyuki Yamasaki

http://www.w3.org/2001/XMLSchema#string

Hiroaki Itamochi

http://www.w3.org/2001/XMLSchema#string

Jinsong Liu

http://www.w3.org/2001/XMLSchema#string

Naoto T Ueno

http://www.w3.org/2001/XMLSchema#string

Seiji Kondo

http://www.w3.org/2001/XMLSchema#string

Takeshi Takahashi

http://www.w3.org/2001/XMLSchema#string

P2860

PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

Reactivity of a monoclonal antibody with human ovarian carcinoma

Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death

A simplified system for generating recombinant adenoviruses

Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action

Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells

Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence

P304

9302-9310

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1158/0008-5472.CAN-08-2592

http://www.w3.org/2001/XMLSchema#string

P407

P433

22

http://www.w3.org/2001/XMLSchema#string

P478

68

http://www.w3.org/2001/XMLSchema#string

P577

2008-11-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

19010903

http://www.w3.org/2001/XMLSchema#string

P921

P932

2676677

http://www.w3.org/2001/XMLSchema#string