PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D - Wikidata - wikimedia - TriplyDB

PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

http://www.wikidata.org/entity/Q35809595

about

On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities Functional regulation of phospholipase D expression in cancer and inflammation Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells.PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage.Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.Cellular and physiological roles for phospholipase D1 in cancer.Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer PLD1 participates in BDNF-induced signalling in cortical neurons Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoter Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP.FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma MiR-206 suppresses epithelial mesenchymal transition by targeting TGF-β signaling in estrogen receptor positive breast cancer cells Phosphatidic acid, phospholipase D and tumorigenesis.Targetting PED/PEA-15 for diabetes treatment.

P2860

Q26799216-6954709F-FAA4-44A2-8825-20D4C989C42E Q26829916-C076084D-6B1E-42DC-90A7-63BA6E5A9ED0 Q27677302-17A59034-33EF-4DA1-AE12-34C77AFA1AA7 Q33587770-C4F0DB4B-0020-4C2C-AF8D-B5B0E6698BB2 Q33743600-9351CB51-43EC-40AA-B006-5C46E227EF28 Q33920841-EFDD44E0-E18E-4C77-A675-BCF8314041F9 Q34024181-E03E4DDA-B09C-41DA-8196-8265EB36E08F Q34044529-F186033F-AEC0-4FCC-A959-BAFECD84F835 Q34268347-42EFE0A6-B9B6-4B96-95C6-F3683E5BA4D9 Q36123489-8644BE49-EA39-47CE-8FB7-6AB90BD3ABFD Q36235303-6CE0554F-12D7-41C7-BCD4-082355C1C706 Q36926900-1A9855BB-ACA2-44D0-BBA4-108E77EF1E2D Q37052955-21FC8D88-8BB1-4180-82F3-629DFA1644CB Q37269357-21FAFEE1-E9D1-400C-8F96-B4DBA84D92D4 Q37624626-5EDD6A89-50A1-4E92-964C-1296EEE9DB2D Q39232367-9408008F-DB8D-41D2-BB9C-84624B4856CF

P2860

PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

http://www.wikidata.org/entity/Q35809595

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

@ast

PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

@en

type

label

PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

@ast

PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

@en

prefLabel

PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

@ast

PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

@en

P1433

Q35809595-A615ADDF-B8DD-4C35-80C7-F38F14992CD8

P1476

Q35809595-B20878CB-FA13-43C7-A7C7-5FB0D1994AD8

P2093

Q35809595-0D561795-20F5-4B3C-8EE1-8F4FDD70AC27

Q35809595-5B2DD1CD-74F5-464C-90C5-AA984728224F

Q35809595-6A04935F-C24F-4771-AD99-8EACA8CFA2F0

Q35809595-71C255E0-6592-41C6-9B99-5A23720E24BC

Q35809595-82A011B4-4E02-49C4-8988-1D1360B51EB3

Q35809595-ADB5C665-6AEE-43AA-B69B-F33923400AA8

Q35809595-F731C59B-09FB-4888-A914-01AE5AB273A0

P2860

Q35809595-017F97B8-9845-4242-9B7A-57C6569EECB8

Q35809595-1FD67246-34C6-472F-892C-5828A90EE8D6

Q35809595-25D7F67D-F800-4A2D-94AD-738B5F6BACE4

Q35809595-277F260C-52AB-4F78-99E1-723C09510B48

Q35809595-2B3123A9-AE47-4B67-9251-CA15778D06BE

Q35809595-3135869D-BFA4-4986-8E00-E447F410E997

Q35809595-3D55E258-E83B-456F-AEB6-835FD115F5AC

Q35809595-414D8AF3-E6BF-4C43-A76A-F8EB2495BF24

Q35809595-499EE616-8A89-41FB-8FE7-A19997EF0B48

Q35809595-5915BBFD-C91E-491E-B28D-8062D7BFA963

P2888

Q35809595-E8E46AC7-DC29-4B15-80E1-1DD2CBAE9B0C

P304

Q35809595-42AAAA59-C31C-4DA1-9682-A1536E19B22F

P31

Q35809595-960A2F19-6F61-4E6B-8E30-246483287CAE

P356

Q35809595-106A887B-6EA5-420F-AD3F-171377CD7A59

P407

Q35809595-96E0087A-1C4D-4094-8DBF-467388711A36

P433

Q35809595-4FCC7E20-FCDD-4542-A49E-6EAE676891DB

P478

Q35809595-0F1372DF-E4EC-4A79-89AD-94030862311B

P50

Q35809595-758945E9-18E3-4B33-B0D5-2E154CF33830

P577

Q35809595-6E1C8C45-8635-4DC4-B8B0-2AE66CAFC786

P5875

Q35809595-950CC4AE-18B3-4D2A-B527-664C5CF0BACA

P6179

Q35809595-4FB7D2D9-D598-41B0-B01D-213324493A8C

P698

Q35809595-CA1EB19D-36E8-4FDA-935C-0C839E18B14F

P932

Q35809595-BD0181DE-D9F7-4194-B101-5077516AEC51

P356

P1433

P1476

PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

@en

P2093

D A Nelson

http://www.w3.org/2001/XMLSchema#string

E P White

http://www.w3.org/2001/XMLSchema#string

F J Sulzmaier

http://www.w3.org/2001/XMLSchema#string

J W Ramos

http://www.w3.org/2001/XMLSchema#string

M J Caliva

http://www.w3.org/2001/XMLSchema#string

M K G Valmiki

http://www.w3.org/2001/XMLSchema#string

M L Matter

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them

The proapoptotic protein Bad binds the amphipathic groove of 14-3-3zeta

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation

NCBI GEO: archive for high-throughput functional genomic data

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.

Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.

P2888

P304

3547-3560

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/ONC.2011.514

http://www.w3.org/2001/XMLSchema#string

P407

P433

30

http://www.w3.org/2001/XMLSchema#string

P478

31

http://www.w3.org/2001/XMLSchema#string

P50

P577

2011-11-21T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51820024

http://www.w3.org/2001/XMLSchema#string

P6179

1049754831

http://www.w3.org/2001/XMLSchema#string

P698

22105357

http://www.w3.org/2001/XMLSchema#string

P932

3295902

http://www.w3.org/2001/XMLSchema#string