PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D
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On the Quest of Cellular Functions of PEA-15 and the Therapeutic OpportunitiesFunctional regulation of phospholipase D expression in cancer and inflammationStructure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPKThe inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells.PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformationPLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage.Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.Cellular and physiological roles for phospholipase D1 in cancer.Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancerPLD1 participates in BDNF-induced signalling in cortical neuronsPhosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoterBisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP.FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinomaMiR-206 suppresses epithelial mesenchymal transition by targeting TGF-β signaling in estrogen receptor positive breast cancer cellsPhosphatidic acid, phospholipase D and tumorigenesis.Targetting PED/PEA-15 for diabetes treatment.
P2860
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P2860
PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D
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2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
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2011年论文
@zh-cn
name
PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D
@ast
PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D
@en
type
label
PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D
@ast
PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D
@en
prefLabel
PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D
@ast
PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D
@en
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P2860
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PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D
@en
P2093
D A Nelson
F J Sulzmaier
M J Caliva
M K G Valmiki
M L Matter
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P2888
P304
P356
10.1038/ONC.2011.514
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P50
P577
2011-11-21T00:00:00Z
P5875
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1049754831