Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains.
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Sequence and analysis of the genome of the pathogenic yeast Candida orthopsilosisGenomic Plasticity of the Human Fungal Pathogen Candida albicansGenetic and phenotypic intra-species variation in Candida albicansEmerging Threats in Antifungal-Resistant Fungal PathogensMechanisms of Candida biofilm drug resistanceTranscriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species ComparisonFungicide-driven evolution and molecular basis of multidrug resistance in field populations of the grey mould fungus Botrytis cinereaAcquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistanceThe transcription factor Ndt80 does not contribute to Mrr1-, Tac1-, and Upc2-mediated fluconazole resistance in Candida albicansGlobal analysis of the evolution and mechanism of echinocandin resistance in Candida glabrataDiscovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossingA novel sterol regulatory element-binding protein gene (sreA) identified in penicillium digitatum is required for prochloraz resistance, full virulence and erg11 (cyp51) regulationInhibitors of the Candida albicans Major Facilitator Superfamily Transporter Mdr1p Responsible for Fluconazole ResistanceGenetic Basis of Antifungal Drug ResistanceEfflux in fungi: la pièce de résistanceAn A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicansGenetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infectionThe role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity.SAGA/ADA complex subunit Ada2 is required for Cap1- but not Mrr1-mediated upregulation of the Candida albicans multidrug efflux pump MDR1Regulatory circuitry governing fungal development, drug resistance, and disease.Rapid mechanisms for generating genome diversity: whole ploidy shifts, aneuploidy, and loss of heterozygosityElucidating drug resistance in human fungal pathogens.Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants.Dur3 is the major urea transporter in Candida albicans and is co-regulated with the urea amidolyase Dur1,2Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.Differential requirement of the transcription factor Mcm1 for activation of the Candida albicans multidrug efflux pump MDR1 by its regulators Mrr1 and Cap1.Multidrug-resistant transporter mdr1p-mediated uptake of a novel antifungal compoundLoss of heterozygosity of FCY2 leading to the development of flucytosine resistance in Candida tropicalis.Stress alters rates and types of loss of heterozygosity in Candida albicans.Loss-of-heterozygosity facilitates passage through Haldane's sieve for Saccharomyces cerevisiae undergoing adaptation.Functional dissection of a Candida albicans zinc cluster transcription factor, the multidrug resistance regulator Mrr1.The evolution of drug resistance in clinical isolates of Candida albicansSREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A).Development of fluconazole resistance in a series of Candida parapsilosis isolates from a persistent candidemia patient with prolonged antifungal therapyClonal Strain Persistence of Candida albicans Isolates from Chronic Mucocutaneous Candidiasis Patients.Fluconazole and Voriconazole Resistance in Candida parapsilosis Is Conferred by Gain-of-Function Mutations in MRR1 Transcription Factor Gene.Acquired Multidrug Antifungal Resistance in Candida lusitaniae during Therapy.Gain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans.Activity of Isavuconazole and Other Azoles against Candida Clinical Isolates and Yeast Model Systems with Known Azole Resistance Mechanisms.Milbemycins: more than efflux inhibitors for fungal pathogens
P2860
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P2860
Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 27 May 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Mutations in the multi-drug re ...... tant Candida albicans strains.
@en
Mutations in the multi-drug re ...... tant Candida albicans strains.
@nl
type
label
Mutations in the multi-drug re ...... tant Candida albicans strains.
@en
Mutations in the multi-drug re ...... tant Candida albicans strains.
@nl
prefLabel
Mutations in the multi-drug re ...... tant Candida albicans strains.
@en
Mutations in the multi-drug re ...... tant Candida albicans strains.
@nl
P2093
P2860
P1476
Mutations in the multi-drug re ...... tant Candida albicans strains.
@en
P2093
Joachim Morschhäuser
Julia Blass
Nico Dunkel
P David Rogers
P2860
P304
P356
10.1111/J.1365-2958.2008.06309.X
P407
P577
2008-05-27T00:00:00Z