Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells.
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What Is Breast in the Bone?The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineageMMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumorsTAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway.Inhibition of hedgehog signaling decreases proliferation and clonogenicity of human mesenchymal stem cells.KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.Hedgehog signaling in the normal and neoplastic mammary gland.ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling.Novel p63 target genes involved in paracrine signaling and keratinocyte differentiation.Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ.The effects of Hedgehog on the RNA-binding protein Msi1 in the proliferation and apoptosis of mesenchymal stem cells.p63 Sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signalingp63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer.Pathway Regulation of p63, a Director of Epithelial Cell FateΔNp63α promotes cellular quiescence via induction and activation of Notch3.Shared signaling pathways in normal and breast cancer stem cells.Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesisΔNp63α expression induces loss of cell adhesion in triple-negative breast cancer cells.The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy.Minireview: hormones and mammary cell fate--what will I become when I grow up?MiR203 mediates subversion of stem cell properties during mammary epithelial differentiation via repression of ΔNP63α and promotes mesenchymal-to-epithelial transition.Cellular quiescence in mammary stem cells and breast tumor stem cells: got testable hypotheses?Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation.Development of mammary tumors by conditional expression of GLI1Hedgehog signalling in breast cancer.p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis.The role of p63 in cancer, stem cells and cancer stem cells.Maintaining epithelial stemness with p63.ΔNp63 regulates cell proliferation, differentiation, adhesion, and migration in the BL2 subtype of basal-like breast cancer.ΔNp63α induces quiescence and downregulates the BRCA1 pathway in estrogen receptor-positive luminal breast cancer cell line MCF7 but not in other breast cancer cell lines.ΔNp63 activates EGFR signaling to induce loss of adhesion in triple-negative basal-like breast cancer cells.ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.Cell lineage determinants as regulators of breast cancer metastasis.Loss of ΔNp63α promotes mitotic exit in epithelial cells.Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease.Daughters of the Enamel Organ: Development, Fate, and Function of the Stratum Intermedium, Stellate Reticulum, and Outer Enamel Epithelium.WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis.EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling.
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Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 21 February 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Reciprocal intraepithelial int ...... oration by mammary stem cells.
@en
Reciprocal intraepithelial int ...... oration by mammary stem cells.
@nl
type
label
Reciprocal intraepithelial int ...... oration by mammary stem cells.
@en
Reciprocal intraepithelial int ...... oration by mammary stem cells.
@nl
prefLabel
Reciprocal intraepithelial int ...... oration by mammary stem cells.
@en
Reciprocal intraepithelial int ...... oration by mammary stem cells.
@nl
P2093
P2860
P1433
P1476
Reciprocal intraepithelial int ...... boration by mammary stem cells
@en
P2093
Baolin Wang
David Robbins
James DiRenzo
Leif W Ellisen
Pratima Cherukuri
Ziqiang Yuan
P2860
P304
P356
10.1634/STEMCELLS.2007-0691
P50
P577
2008-02-21T00:00:00Z