The molecular signature of CD8+ T cells undergoing deletional tolerance
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Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor ImmunityCell death in the maintenance and abrogation of tolerance: the five Ws of dying cellsImmature and maturation-resistant human dendritic cells generated from bone marrow require two stimulations to induce T cell anergy in vitro.The power and the promise of restimulation-induced cell death in human immune diseases.Immunological tolerance to muscle autoantigens involves peripheral deletion of autoreactive CD8+ T cellsOX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patientsInnate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161(hi) CD8α⁺ semi-invariant T cellsThe pro-apoptotic BH3-only protein Bim interacts with components of the translocase of the outer mitochondrial membrane (TOM)Δ9-tetrahydrocannabinol suppresses cytotoxic T lymphocyte function independent of CB1 and CB 2, disrupting early activation events.Elevated tumor-associated antigen expression suppresses variant peptide vaccine responses.BTLA marks a less-differentiated tumor-infiltrating lymphocyte subset in melanoma with enhanced survival properties.Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes.B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells.Durable adoptive immunotherapy for leukemia produced by manipulation of multiple regulatory pathways of CD8+ T-cell tolerance.Oral-tolerization Prevents Immune Responses and Improves Transgene Persistence Following Gene Transfer Mediated by Adeno-associated Viral Vector.Tolerance of Tumor-Specific T cells in Melanoma MetastasesRecent thymic emigrants are tolerized in the absence of inflammation.Asymptomatic memory CD8+ T cells: from development and regulation to consideration for human vaccines and immunotherapeuticsMannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4.Effects of RANKL-Targeted Therapy in Immunity and Cancer.Diversity in CD8(+) T cell differentiation.E3 ubiquitin ligases in T-cell tolerance.Immunodrugs: breaking B- but not T-cell tolerance with therapeutic anticytokine vaccines.Modulation of Immune Cell Functions by the E3 Ligase Cbl-b.Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa.T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases.Molecular Profile of Tumor-Specific CD8+ T Cell Hypofunction in a Transplantable Murine Cancer Model.FOXO3 is differentially required for CD8(+) T-cell death during tolerance versus immunity.Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigensT-cell tolerance: central and peripheralA distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapy.Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis.Peripheral Deletion of CD8 T Cells Requires p38 MAPK in Cross-Presenting Dendritic Cells.Forced expression of IL-7R promotes CD8 T cell cytotoxicity to self antigen.
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The molecular signature of CD8+ T cells undergoing deletional tolerance
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 February 2009
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vetenskaplig artikel
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videnskabelig artikel
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The molecular signature of CD8+ T cells undergoing deletional tolerance
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The molecular signature of CD8+ T cells undergoing deletional tolerance.
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The molecular signature of CD8+ T cells undergoing deletional tolerance
@en
The molecular signature of CD8+ T cells undergoing deletional tolerance.
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prefLabel
The molecular signature of CD8+ T cells undergoing deletional tolerance
@en
The molecular signature of CD8+ T cells undergoing deletional tolerance.
@nl
P2093
P2860
P50
P1433
P1476
The molecular signature of CD8+ T cells undergoing deletional tolerance
@en
P2093
Gareth S Denyer
Torsten Juelich
P2860
P304
P356
10.1182/BLOOD-2008-10-185223
P407
P577
2009-02-09T00:00:00Z