Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.
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Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9)Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoidsProviding a molecular mechanism for P-glycoprotein; why would I bother?Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.Crystal structure of a heterodimeric ABC transporter in its inward-facing conformationStructural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog.The yeast a-factor transporter Ste6p, a member of the ABC superfamily, couples ATP hydrolysis to pheromone export.Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt diseaseThe human cytomegalovirus gene product US6 inhibits ATP binding by TAPNSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistanceOptimized purification of a heterodimeric ABC transporter in a highly stable form amenable to 2-D crystallizationScreening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interferenceTherapeutic strategies to improve drug delivery across the blood-brain barrier.Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes.Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains.Merck Frosst Award Lecture 1998. Molecular dissection of the human multidrug resistance P-glycoprotein.The detergent-soluble maltose transporter is activated by maltose binding protein and verapamil.Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding siteCystic fibrosis transmembrane conductance regulator mutations that disrupt nucleotide bindingTopoisomerase I inhibition with topotecan: pharmacologic and clinical issues.Multidrug resistance ABC transporters.Cloning and regulation of the rat mdr2 geneRequirement for metabolic activation of acetylaminofluorene to induce multidrug gene expression.Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein.Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: possible role for drug efflux in drug resistance.Hydrogel-assisted functional reconstitution of human P-glycoprotein (ABCB1) in giant liposomes.Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.Cell biological mechanisms of multidrug resistance in tumors.Kinetic validation of the models for P-glycoprotein ATP hydrolysis and vanadate-induced trapping. Proposal for additional steps.Unidirectional fluxes of rhodamine 123 in multidrug-resistant cells: evidence against direct drug extrusion from the plasma membrane.Structure and function of efflux pumps that confer resistance to drugsIdentification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators.Kuguacin J isolated from Momordica charantia leaves inhibits P-glycoprotein (ABCB1)-mediated multidrug resistance.Mutagenesis of the putative nucleotide-binding domains of the multidrug resistance associated protein (MRP). Analysis of the effect of these mutations on MRP mediated drug resistance and transportP-glycoprotein structure and evolutionary homologies.Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications.The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research.Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.Evidence for two nonidentical drug-interaction sites in the human P-glycoproteinChanges in intra- or extracellular pH do not mediate P-glycoprotein-dependent multidrug resistance.
P2860
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P2860
Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Partial purification and recon ...... g-stimulatable ATP hydrolysis.
@en
Partial purification and recon ...... g-stimulatable ATP hydrolysis.
@nl
type
label
Partial purification and recon ...... g-stimulatable ATP hydrolysis.
@en
Partial purification and recon ...... g-stimulatable ATP hydrolysis.
@nl
prefLabel
Partial purification and recon ...... g-stimulatable ATP hydrolysis.
@en
Partial purification and recon ...... g-stimulatable ATP hydrolysis.
@nl
P2093
P2860
P356
P1476
Partial purification and recon ...... g-stimulatable ATP hydrolysis.
@en
P2093
Ambudkar SV
Cardarelli CO
Gottesman MM
P2860
P304
P356
10.1073/PNAS.89.18.8472
P407
P577
1992-09-01T00:00:00Z