Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. - Wikidata - wikimedia - TriplyDB

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.

http://www.wikidata.org/entity/Q37198891

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ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology Epigenetic pathways and glioblastoma treatment Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2 BRCA1 is a negative modulator of the PRC2 complex miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis A decade of exploring the cancer epigenome - biological and translational implications Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy Regulation of T Cell Differentiation and Function by EZH2 MicroRNAs as Biomarkers for Diagnosis, Prognosis and Theranostics in Prostate Cancer Role of Noncoding RNAs as Biomarker and Therapeutic Targets for Liver Fibrosis The complexity of epigenetic diseases Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications The effects of microRNA on the absorption, distribution, metabolism and excretion of drugs Noncoding RNA in oncogenesis: a new era of identifying key players Linking epithelial-to-mesenchymal-transition and epigenetic modifications The Akt-associated microRNAs MicroRNAs in autophagy and their emerging roles in crosstalk with apoptosis MicroRNAs that affect prostate cancer: emphasis on prostate cancer in African Americans Anticancer activity of green tea polyphenols in prostate gland Systemic delivery of microRNA-101 potently inhibits hepatocellular carcinoma in vivo by repressing multiple targets Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations Integrating Epigenomics into the Understanding of Biomedical Insight EZH2 in Bladder Cancer, a Promising Therapeutic Target Key nodes of a microRNA network associated with the integrated mesenchymal subtype of high-grade serous ovarian cancer Diverse involvement of EZH2 in cancer epigenetics Epigenetic regulation in human melanoma: past and future Synthetic reversal of epigenetic silencing The role of EZH2 in tumour progression Downregulation of microRNA-23a suppresses prostate cancer metastasis by targeting the PAK6-LIMK1 signaling pathway The potential value of microseminoprotein-beta as a prostate cancer biomarker and therapeutic target MicroRNA-101 is a potential prognostic indicator of laryngeal squamous cell carcinoma and modulates CDK8 Downregulation of miR-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth Genetic variation in a hsa-let-7 binding site in RAD52 is associated with breast cancer susceptibility microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation

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P2860

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.

http://www.wikidata.org/entity/Q37198891

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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name

Genomic loss of microRNA-101 l ...... hyltransferase EZH2 in cancer.

@en

Genomic loss of microRNA-101 l ...... hyltransferase EZH2 in cancer.

@nl

type

label

Genomic loss of microRNA-101 l ...... hyltransferase EZH2 in cancer.

@en

Genomic loss of microRNA-101 l ...... hyltransferase EZH2 in cancer.

@nl

prefLabel

Genomic loss of microRNA-101 l ...... hyltransferase EZH2 in cancer.

@en

Genomic loss of microRNA-101 l ...... hyltransferase EZH2 in cancer.

@nl

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SCIENCE.1165395

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Genomic loss of microRNA-101 l ...... hyltransferase EZH2 in cancer.

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Arul M Chinnaiyan

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Bharathi Laxman

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Bo Han

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Christopher A Maher

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J Chad Brenner

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Jindan Yu

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Jung H Kim

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Kalpana Ramnarayanan

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Patrick Tan

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Ram-Shankar Mani

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Human MicroRNA targets

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

MicroInspector: a web tool for detection of miRNA binding sites in an RNA sequence.

Prediction of mammalian microRNA targets

Combinatorial microRNA target predictions

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

Silencing of microRNAs in vivo with 'antagomirs'

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

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1695-1699

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10.1126/SCIENCE.1165395

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5908

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322

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Nallasivam Palanisamy

Sooryanarayana Varambally

Chandan Kumar-Sinha

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2008-11-13T00:00:00Z

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23472800

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19008416

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2684823

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