Boom in the development of non-peptidic beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease.
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Computational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β -SecretasePicomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime RegionA Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-SecretaseThe secretases: enzymes with therapeutic potential in Alzheimer disease.Novel phenyl(thio)ureas bearing (thio)oxothiazoline group as potential BACE-1 inhibitors: synthesis and biological evaluation.Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell lineInhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.Current and future treatments for Alzheimer's diseaseSynthesis of a targeted library of heparan sulfate hexa- to dodecasaccharides as inhibitors of β-secretase: potential therapeutics for Alzheimer's disease.Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system.BACE1 as a potential biomarker for Alzheimer's diseaseNaturally Inspired Molecules as Multifunctional Agents for Alzheimer's Disease Treatment.Gene therapy in Alzheimer's disease - potential for disease modificationThe role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's diseaseThe beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential.Application of computational methods for the design of BACE-1 inhibitors: validation of in silico modelling.Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions.Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors.The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease.Treatment strategies targeting amyloid β-protein.BACE1 influences debris clearance and axonal regeneration in injured peripheral nerve.The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.Design and Synthesis of Novel Arylketo-containing P1-P3 Linked Macro-cyclic BACE-1 InhibitorsModulation of in vitro activity of zymogenic and mature recombinant human β-secretase by dietary plants.Factors Influencing the Potency of Alzheimer Inhibitors: Computational and Docking Studies.Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles.Synthesis of amino heterocycle aspartyl protease inhibitors.Synthesis, in vitro biological evaluation and molecular docking studies of benzimidamides as potential BACE1 inhibitors.Sequential Virtual Screening Approach to the Identification of Small Organic Molecules as Potential BACE-1 Inhibitors
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Boom in the development of non-peptidic beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Boom in the development of non ...... atment of Alzheimer's disease.
@en
Boom in the development of non-peptidic beta-secretase
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type
label
Boom in the development of non ...... atment of Alzheimer's disease.
@en
Boom in the development of non-peptidic beta-secretase
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prefLabel
Boom in the development of non ...... atment of Alzheimer's disease.
@en
Boom in the development of non-peptidic beta-secretase
@nl
P356
P1476
Boom in the development of non ...... atment of Alzheimer's disease.
@en
P2093
Romano Silvestri
P2860
P304
P356
10.1002/MED.20132
P577
2009-03-01T00:00:00Z