The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential.
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Imperatorin–pharmacological meaning and analytical clues: profound investigationAmyloid precursor protein and amyloid precursor-like protein 2 in cancerAlzheimer's therapeutics: translation of preclinical science to clinical drug developmentAxonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cellsAlzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasisAmyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation.APP processing in Alzheimer's diseaseDeficiency of the copper chaperone for superoxide dismutase increases amyloid-β productionA novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicityAlzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful agingBACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous systemFerulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic miceTetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent AutophagyConformational Dynamics and Binding Free Energies of Inhibitors of BACE-1: From the Perspective of Protonation EquilibriaMossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptorsDepletion of GGA1 and GGA3 mediates postinjury elevation of BACE1γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF AβChemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitorsS-glutathionylation: from molecular mechanisms to health outcomesPhospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits.A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.Increased γ-secretase activity in idiopathic normal pressure hydrocephalus patients with β-amyloid pathology.Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons.Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons.Sortilin Fragments Deposit at Senile Plaques in Human CerebrumProtective Effects of Wogonin against Alzheimer's Disease by Inhibition of Amyloidogenic Pathway.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.RTN/Nogo in forming Alzheimer's neuritic plaques.Analysis of mouse brain peptides using mass spectrometry-based peptidomics: implications for novel functions ranging from non-classical neuropeptides to microproteins.Inhibition of BACE1 for therapeutic use in Alzheimer's disease.Ubiquitin regulates GGA3-mediated degradation of BACE1Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion.Divalent cation tolerance protein binds to β-secretase and inhibits the processing of amyloid precursor protein.Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer diseaseBACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseIntraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease.Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models.
P2860
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P2860
The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The beta-secretase enzyme BACE ...... on, and therapeutic potential.
@en
The beta-secretase enzyme BACE ...... on, and therapeutic potential.
@nl
type
label
The beta-secretase enzyme BACE ...... on, and therapeutic potential.
@en
The beta-secretase enzyme BACE ...... on, and therapeutic potential.
@nl
prefLabel
The beta-secretase enzyme BACE ...... on, and therapeutic potential.
@en
The beta-secretase enzyme BACE ...... on, and therapeutic potential.
@nl
P2093
P2860
P1476
The beta-secretase enzyme BACE ...... on, and therapeutic potential.
@en
P2093
Dora M Kovacs
Philip C Wong
Riqiang Yan
Robert Vassar
P2860
P304
12787-12794
P356
10.1523/JNEUROSCI.3657-09.2009
P407
P577
2009-10-01T00:00:00Z