FERM control of FAK function: implications for cancer therapy. - Wikidata - wikimedia - TriplyDB

FERM control of FAK function: implications for cancer therapy.

FERM control of FAK function: implications for cancer therapy.

http://www.wikidata.org/entity/Q37234240

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Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival Nuclear FAK: a new mode of gene regulation from cellular adhesions An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans Mechanistic evaluation of a novel small molecule targeting mitochondria in pancreatic cancer cells p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation.β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy Focal adhesion kinase and endothelial cell apoptosis.Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer.Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream.Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling.Regulation of blood-testis barrier dynamics by focal adhesion kinase (FAK): an unexpected turn of events Significance of talin in cancer progression and metastasis.Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis Selection in spatial stochastic models of cancer: migration as a key modulator of fitness Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytes Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.Non-Smad transforming growth factor-β signaling regulated by focal adhesion kinase binding the p85 subunit of phosphatidylinositol 3-kinase.Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights Role of focal adhesion kinase in oocyte-follicle communication.Inhibition of podocyte FAK protects against proteinuria and foot process effacement.New insights into FAK phosphorylation based on a FAT domain-defective mutation In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking FAK is overexpressed in keratocystic odontogenic tumor: a preliminary study.Focal Adhesion Kinase: Insight into Molecular Roles and Functions in Hepatocellular Carcinoma Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways.Visualizing and manipulating focal adhesion kinase regulation in live cells.Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression.pH sensing by FAK-His58 regulates focal adhesion remodeling The effects of cell compressibility, motility and contact inhibition on the growth of tumor cell clusters using the Cellular Potts Model.Progress in researches about focal adhesion kinase in gastrointestinal tract.Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer.Mechanosensitive signalling in fish gill and other ion transporting epithelia.Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis.RNA interference in the clinic: challenges and future directions.Cross talk between focal adhesion kinase and cadherins: role in regulating endothelial barrier function.The diverse roles and multiple forms of focal adhesion kinase in brain.

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FERM control of FAK function: implications for cancer therapy.

http://www.wikidata.org/entity/Q37234240

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 29 May 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

FERM control of FAK function: implications for cancer therapy.

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FERM control of FAK function: implications for cancer therapy.

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FERM control of FAK function: implications for cancer therapy.

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FERM control of FAK function: implications for cancer therapy.

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FERM control of FAK function: implications for cancer therapy.

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FERM control of FAK function: implications for cancer therapy.

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FERM control of FAK function: implications for cancer therapy

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David D Schlaepfer

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David Mikolon

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Dwayne G Stupack

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P2860

Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway

Integrin-regulated FAK-Src signaling in normal and cancer cells

Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53

Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation

The protein kinase complement of the human genome

Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases

Structural basis for the autoinhibition of focal adhesion kinase

Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271

Cell signaling by receptor tyrosine kinases

Integrins: bidirectional, allosteric signaling machines

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2306-2314

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scholarly article

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10.4161/CC.6367

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15

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7

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2008-05-29T00:00:00Z

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