Cellular immune response to cryptic epitopes during therapeutic gene transfer. - Wikidata - wikimedia - TriplyDB

Cellular immune response to cryptic epitopes during therapeutic gene transfer.

Cellular immune response to cryptic epitopes during therapeutic gene transfer.

http://www.wikidata.org/entity/Q37250034

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Direct detection of alternative open reading frames translation products in human significantly expands the proteome Developments in the treatment of hemophilia B: focus on emerging gene therapy Gene therapy on the move Animal models of hemophilia Cardiac-targeted delivery of regulatory RNA molecules and genes for the treatment of heart failure AAV's anatomy: roadmap for optimizing vectors for translational success The pleiotropic effects of natural AAV infections on liver-directed gene transfer in macaques Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.Viral vectors for neurotrophic factor delivery: a gene therapy approach for neurodegenerative diseases of the CNS Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them.Adeno-associated virus vectors serotype 2 induce prolonged proliferation of capsid-specific CD8+ T cells in mice.Non-conventional sources of peptides presented by MHC class I.Systemic elimination of de novo capsid protein synthesis from replication-competent AAV contamination in the liver Codon optimization of the human papillomavirus E7 oncogene induces a CD8+ T cell response to a cryptic epitope not harbored by wild-type E7 Adenovirus-associated virus vector-mediated gene transfer in hemophilia B Preclinical evaluation of a clinical candidate AAV8 vector for ornithine transcarbamylase (OTC) deficiency reveals functional enzyme from each persisting vector genome.Vector Design for Improved DNA Vaccine Efficacy, Safety and Production.Integration frequency and intermolecular recombination of rAAV vectors in non-human primate skeletal muscle and liver.Enhanced Recognition of HIV-1 Cryptic Epitopes Restricted by HLA Class I Alleles Associated With a Favorable Clinical Outcome.Death of a dogma: eukaryotic mRNAs can code for more than one protein.Adeno-associated virus capsid antigen presentation is dependent on endosomal escape.Adeno-associated viral vectors for the treatment of hemophilia.Kinetics of adeno-associated virus serotype 2 (AAV2) and AAV8 capsid antigen presentation in vivo are identical.Immune responses to AAV vectors: overcoming barriers to successful gene therapy Nowhere to hide: unconventional translation yields cryptic peptides for immune surveillance Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules.A translationally optimized AAV-UGT1A1 vector drives safe and long-lasting correction of Crigler-Najjar syndrome.Oversized AAV transductifon is mediated via a DNA-PKcs-independent, Rad51C-dependent repair pathway.Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies Gene therapy for haemophilia: a long and winding road.Recent Developments in Gene Therapy for Homozygous Familial Hypercholesterolemia.Small proteins encoded by unannotated ORFs are rising stars of the proteome, confirming shortcomings in genome annotations and current vision of an mRNA.Liver-Directed Adeno-Associated Viral Gene Therapy for Hemophilia.Presentation of Cryptic Peptides by MHC Class I Is Enhanced by Inflammatory Stimuli.AAV vector-meditated expression of HLA-G reduces injury-induced corneal vascularization, immune cell infiltration, and fibrosis.Inhibition of antigen presentation during AAV gene therapy using virus peptides.

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Cellular immune response to cryptic epitopes during therapeutic gene transfer.

http://www.wikidata.org/entity/Q37250034

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 16 June 2009

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Cellular immune response to cryptic epitopes during therapeutic gene transfer.

@en

Cellular immune response to cryptic epitopes during therapeutic gene transfer.

@nl

type

label

Cellular immune response to cryptic epitopes during therapeutic gene transfer.

@en

Cellular immune response to cryptic epitopes during therapeutic gene transfer.

@nl

prefLabel

Cellular immune response to cryptic epitopes during therapeutic gene transfer.

@en

Cellular immune response to cryptic epitopes during therapeutic gene transfer.

@nl

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PNAS.0902269106

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Proceedings of the National Academy of Sciences of the United States of America

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Cellular immune response to cryptic epitopes during therapeutic gene transfer.

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Aravind Asokan

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Chengwen Li

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David Seiber

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Jeff Alexander

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Jeff Frelinger

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John Sidney

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Junjiang Sun

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Kevin Goudy

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Matt Hirsch

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Paul Monahan

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P2860

Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens.

Identification of mouse AAV capsid-specific CD8+ T cell epitopes.

Adeno-associated virus serotypes: vector toolkit for human gene therapy.

Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo

Identification of cryptic MHC I-restricted epitopes encoded by HIV-1 alternative reading frames

Alternative translational products and cryptic T cell epitopes: expecting the unexpected.

Novel transcriptional regulatory signals in the adeno-associated virus terminal repeat A/D junction element.

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10770-10774

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26

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106

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Alessandro Sette

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2009-06-16T00:00:00Z

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