SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway.
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Crystal structure of domain-swapped STE20 OSR1 kinase domainAmeliorated ConA-induced hepatitis in the absence of PKC-thetaOverexpression of Ste20-related proline/alanine-rich kinase exacerbates experimental colitis in miceStructural and biochemical insights into the activation mechanisms of germinal center kinase OSR1.Ste20-related proline/alanine-rich kinase (SPAK) regulated transcriptionally by hyperosmolarity is involved in intestinal barrier function.Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells.The SWI/SNF chromatin-remodeling complex modulates peripheral T cell activation and proliferation by controlling AP-1 expression.On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl- cotransport activityCharacterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation.C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signalingIschemia-induced stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport involves p38 and JNK MAP kinases.Protein kinase C and beyond.Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.A novel role for CD46 in wound repairMST-4 and TRAF-6 expression in the peripheral blood mononuclear cells of patients with Graves' disease and its significance.The PKCθ pathway participates in the aberrant accumulation of Fra-1 protein in invasive ER-negative breast cancer cells.A critical role for protein kinase C-theta-mediated T cell survival in cardiac allograft rejection.Protein kinase C theta (PKCtheta): a key player in T cell life and deathMultigene kinase network, kidney transport, and salt in essential hypertension.Nuclear factor-kappaB is a critical mediator of Ste20-like proline-/alanine-rich kinase regulation in intestinal inflammationBCL11B enhances TCR/CD28-triggered NF-kappaB activation through up-regulation of Cot kinase gene expression in T-lymphocytes.Differential requirement of PKC-theta in the development and function of natural regulatory T cells.Ste20-related proline/alanine-rich kinase: a novel regulator of intestinal inflammation.Epigenetic silencing of Stk39 in B-cell lymphoma inhibits apoptosis from genotoxic stress.No specific subcellular localization of protein kinase C is required for cytotoxic T cell granule exocytosis.Physiology and pathophysiology of SLC12A1/2 transporters.The yin and yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression.Germinal center kinases in immune regulation.Kinase regulation of Na+-K+-2Cl- cotransport in primary afferent neurons.PKC-θ function at the immunological synapse: prospects for therapeutic targeting.SPAK mediates KCC3-enhanced cervical cancer tumorigenesis.PKCdelta acts upstream of SPAK in the activation of NKCC1 by hyperosmotic stress in human airway epithelial cells.PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription.Role for protein kinase Ctheta (PKCtheta) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-kappaB activation.Intervention of PKC-θ as an immunosuppressive regimen.PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors.Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4.Human immunodeficiency virus reactivation by phorbol esters or T-cell receptor ligation requires both PKCalpha and PKCtheta.
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P2860
SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 26 February 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
SPAK kinase is a substrate and ...... duced AP-1 activation pathway.
@en
SPAK kinase is a substrate and ...... duced AP-1 activation pathway.
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type
label
SPAK kinase is a substrate and ...... duced AP-1 activation pathway.
@en
SPAK kinase is a substrate and ...... duced AP-1 activation pathway.
@nl
prefLabel
SPAK kinase is a substrate and ...... duced AP-1 activation pathway.
@en
SPAK kinase is a substrate and ...... duced AP-1 activation pathway.
@nl
P2093
P2860
P356
P1433
P1476
SPAK kinase is a substrate and ...... duced AP-1 activation pathway.
@en
P2093
Amnon Altman
Binggang Sun
Hiroki Tabata
Randi Vita
Yingqiu Li
P2860
P304
P356
10.1038/SJ.EMBOJ.7600125
P407
P577
2004-02-26T00:00:00Z