Roles of the cation-chloride cotransporters in neurological disease.
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Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmissionSimilar effects of all WNK3 variants on SLC12 cotransportersWNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransportersThe WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transportersNMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currentsThe neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spinesPlasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic BrainDisruption of ion homeostasis in the neurogliovascular unit underlies the pathogenesis of ischemic cerebral edemaK-Cl cotransporters, cell volume homeostasis, and neurological diseaseModulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2Current view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2Stress, seizures, and hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsyNeuronal and astroglial correlates underlying spatiotemporal intrinsic optical signal in the rat hippocampal sliceAbnormal chloride homeostasis in the substancia nigra pars reticulata contributes to locomotor deficiency in a model of acute liver injuryModeling glial contributions to seizures and epileptogenesis: cation-chloride cotransporters in Drosophila melanogasterGABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy.Molecular and evolutionary insights into the structural organization of cation chloride cotransportersMolecular mechanisms of epilepsyNovel treatment targets for cerebral edemaA trafficking-deficient mutant of KCC3 reveals dominant-negative effects on K-Cl cotransport functionA stress steroid triggers anxiety via increased expression of α4βδ GABAA receptors in methamphetamine dependence.Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures.A sensitive period of mice inhibitory system to neonatal GABA enhancement by vigabatrin is brain region dependentSearching for the ideal antiepileptogenic agent in experimental models: single treatment versus combinatorial treatment strategiesAge- and sex-dependent susceptibility to phenobarbital-resistant neonatal seizures: role of chloride co-transportersDisturbed sensorimotor and electrophysiological patterns in lead intoxicated rats during development are restored by curcumin I.NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide.Targeting brain-derived neurotrophic factor in the medial thalamus for the treatment of central poststroke pain in a rodent model.Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-α and IL-1β-induced Na-K-Cl Cotransporter up-regulation.Pre & postsynaptic tuning of action potential timing by spontaneous GABAergic activityDecreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1.Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital.Anomalous expression of chloride transporters in the sclerosed hippocampus of mesial temporal lobe epilepsy patientsInflux of calcium through L-type calcium channels in early postnatal regulation of chloride transporters in the rat hippocampusChloride extrusion enhancers as novel therapeutics for neurological diseasesKinetics of hyperosmotically stimulated Na-K-2Cl cotransporter in Xenopus laevis oocytesInhibition of NKCC1 attenuated hippocampal LTP formation and inhibitory avoidance in rat.The role of GABA in the regulation of GnRH neurons
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Roles of the cation-chloride cotransporters in neurological disease.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2008
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Roles of the cation-chloride cotransporters in neurological disease.
@en
Roles of the cation-chloride cotransporters in neurological disease.
@nl
type
label
Roles of the cation-chloride cotransporters in neurological disease.
@en
Roles of the cation-chloride cotransporters in neurological disease.
@nl
prefLabel
Roles of the cation-chloride cotransporters in neurological disease.
@en
Roles of the cation-chloride cotransporters in neurological disease.
@nl
P2093
P356
P1476
Roles of the cation-chloride cotransporters in neurological disease
@en
P2093
David B Mount
Kevin J Staley
Kristopher T Kahle
Richard P Lifton
Steven C Hebert
P304
P356
10.1038/NCPNEURO0883
P577
2008-09-01T00:00:00Z