Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
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Fundamentals of cancer metabolismPancreatic cancer from bench to bedside: molecular pathways and treatment optionsKRAS Mutant Pancreatic Cancer: No Lone Path to an Effective TreatmentGenetics and biology of pancreatic ductal adenocarcinomaLeaving the lysosome behind: novel developments in autophagy inhibitionHypoxia and metabolic adaptation of cancer cellsLipid metabolic reprogramming in cancer cellsCell-Penetrating Peptide as a Means of Directing the Differentiation of Induced-Pluripotent Stem CellsPancreatic Cancer Metabolism: Breaking It Down to Build It Back UpDysregulated metabolism contributes to oncogenesisOncogenes strike a balance between cellular growth and homeostasisAmino acid management in cancerSurface-Enhanced Raman Spectroscopy: A New Modality for Cancer ImagingOrchestrating the Tumor Microenvironment to Improve Survival for Patients With Pancreatic Cancer: Normalization, Not DestructionAutophagy in cellular metabolism and cancerAlternative fuels for cancer cellsSmall GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturationGrowth factor signaling to mTORC1 by amino acid-laden macropinosomes.Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages.Regulation of Macropinocytosis by Diacylglycerol Kinase ζDelivery of CSF-1R to the lumen of macropinosomes promotes its destruction in macrophages.Understanding cachexia as a cancer metabolism syndromeMacropinocytosis Exploitation by Cancers and Cancer TherapeuticsDrugging the addict: non-oncogene addiction as a target for cancer therapyMetabolic pathways promoting cancer cell survival and growthProtein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylationPhosphatidylinositol 3-Kinase-Associated Protein (PI3KAP)/XB130 Crosslinks Actin Filaments through Its Actin Binding and Multimerization Properties In Vitro and Enhances Endocytosis in HEK293 CellsHydrocarbon-stapled peptides: principles, practice, and progressApolipoprotein A-II Plus Lipid Emulsion Enhance Cell Growth via SR-B1 and Target Pancreatic Cancer In Vitro and In VivoTumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolismOverexpression of atypical protein kinase C in HeLa cells facilitates macropinocytosis via Src activationPIP₃-dependent macropinocytosis is incompatible with chemotaxisSequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.High-content analysis of antibody phage-display library selection outputs identifies tumor selective macropinocytosis-dependent rapidly internalizing antibodies.Selective localization of myosin-I proteins in macropinosomes and actin waves.Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion.A plasma membrane template for macropinocytic cups.Starved epithelial cells uptake extracellular matrix for survival.Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis.Estimation of flux ratios without uptake or release data: Application to serine and methionine metabolism.
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Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 May 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
@en
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.
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type
label
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
@en
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.
@nl
prefLabel
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
@en
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.
@nl
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P2860
P356
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P1476
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
@en
P2093
Christian M Metallo
Cosimo Commisso
Craig B Thompson
Elda Grabocka
Jeffrey A Drebin
Joshua D Rabinowitz
Jurre J Kamphorst
Matthew G Vander Heiden
Michel Nofal
Rengin G Soydaner-Azeloglu
P2860
P2888
P304
P356
10.1038/NATURE12138
P407
P577
2013-05-12T00:00:00Z
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P6179
1051022800