Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M.
about
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stabilityMHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCMFAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathwayFanconi anemia complementation group A (FANCA) protein has intrinsic affinity for nucleic acids with preference for single-stranded formsHow the fanconi anemia pathway guards the genomeCellular response to DNA interstrand crosslinks: the Fanconi anemia pathwayFunctions and regulation of the multitasking FANCM family of DNA motor proteinsInhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer TherapyThe MHF complex senses branched DNA by binding a pair of crossover DNA duplexesForkhead transcription factor FoxF1 interacts with Fanconi anemia protein complexes to promote DNA damage responseExpanded roles of the Fanconi anemia pathway in preserving genomic stabilityA never-ending story: the steadily growing family of the FA and FA-like genesAluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.ATR-dependent phosphorylation of FANCM at serine 1045 is essential for FANCM functions.Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cellsFanconi anemia proteins and their interacting partners: a molecular puzzleATR activation and replication fork restart are defective in FANCM-deficient cells.The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability.The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint responseFANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling.The genetic and biochemical basis of FANCD2 monoubiquitinationHypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signalingDistribution and medical impact of loss-of-function variants in the Finnish founder population.Correct mRNA processing at a mutant TT splice donor in FANCC ameliorates the clinical phenotype in patients and is enhanced by delivery of suppressor U1 snRNAs.The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair.Exome sequencing identifies FANCM as a susceptibility gene for triple-negative breast cancerFANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis.Homologous recombination-dependent rescue of deficiency in the structural maintenance of chromosomes (Smc) 5/6 complex.Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations.Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein.Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatinChromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks.Primary Ovarian Insufficiency Induced by Fanconi Anemia E Mutation in a Mouse Model.FANCM c.5791C>T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factorDearth and Delayed Maturation of Testicular Germ Cells in Fanconi Anemia E Mutant Male MiceRegulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4.FANCM and FAAP24 maintain genome stability via cooperative as well as unique functionsDifferential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1.The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma.Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery.
P2860
Q24304973-06C0D404-3CD9-4BCF-B40B-2C07BD77D189Q24305020-25CF91BD-FC79-4AC8-A9D1-789E93A0C37CQ24305406-B11D5BDE-652E-4702-B27F-D53DFD63DB4CQ24631719-BD55173E-A743-407A-8781-E9B4049EB369Q24634556-CDC339C7-0E21-4E57-8D51-0F4C14280407Q26752319-A5489B0F-E104-4852-8DE3-B607042DE9E5Q26784076-E459423D-9F90-4292-92D8-21C229F8DB11Q26796576-C332AC11-FCE5-472B-B3CD-5D2F81C2F656Q27681193-54FAB870-09FA-4841-AB22-9BE1692C11D9Q28270475-9F88098F-9818-4691-A0A4-CB2A2E910005Q28749668-50D64D44-9E26-4078-BEB6-B0ED6E64909FQ30100995-0EC78F6B-44C2-4423-B42C-283A3FA27256Q30371243-DF6EC7B7-5C66-43CA-A571-225E65001F4FQ30411898-123B9BAA-2675-478C-B00B-0439E67F6880Q30497160-5ECD2A60-EA34-4C90-9A00-CDF215973EDDQ33353826-BAE134FD-55F9-4F4C-8031-B00D28D1336DQ33522555-0D37CB09-2696-4271-9A74-83EA85434D8CQ33571367-3FE1410F-CD98-4D83-A36F-C12B9C765C62Q33645185-E6865F89-4DBD-4741-819A-C0732D8C7046Q33690563-40C48DEC-6D32-4A14-970B-DD0039EE5889Q33735561-4FC52A91-13C9-4157-AEAB-A96F52F93613Q33880788-BA2FEC05-BD81-4966-A29C-490A9F9089A8Q33981677-E82ED6B8-4B65-4095-9706-7368C5C07816Q34169373-F539E755-81A2-427D-91B3-DB500DE3A6BEQ34277577-E1223DD7-E7B4-4B69-A354-15DB640DF290Q34408752-5385DA0E-823F-4D65-AFC4-300D9A58B7B6Q34482867-5389982E-600B-4CFC-B170-5391271F5E3FQ34568333-BB8B92D7-A369-46EB-A102-AF00F4744B00Q34870512-C586FD67-030C-471D-AF5D-594BCB97D549Q35028557-0A995FD6-00F4-4EB5-AFEF-7F1352E215B4Q35742521-3FA437C9-397F-42C5-A624-5B0497AA32D1Q35893816-F191E754-C441-4054-8A1F-CF820AF91BBAQ35944882-3765F553-545A-4061-BA53-FE3413AACA97Q35999309-DDA9CD0E-F6C5-4D78-BA6F-FB97A034A28DQ36093679-D6DE07E6-0881-4A8F-9EBA-BBA51A88DAD2Q36512615-F286C3F9-68AB-4CC1-A5D1-1938BC5DFF86Q36677983-BAC8A9C2-CE85-4FBF-BAAE-FCFA047051F9Q36715620-329E4F1D-3458-41A8-B54B-81CD37271848Q36867985-9E7D4AC1-307D-4A5B-8FCB-E9A4804A27CDQ37022214-7A6B76DC-0E4B-4998-A825-20A1940982EF
P2860
Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 07 May 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Impaired FANCD2 monoubiquitina ...... nemia complementation group M.
@en
Impaired FANCD2 monoubiquitina ...... nemia complementation group M.
@nl
type
label
Impaired FANCD2 monoubiquitina ...... nemia complementation group M.
@en
Impaired FANCD2 monoubiquitina ...... nemia complementation group M.
@nl
prefLabel
Impaired FANCD2 monoubiquitina ...... nemia complementation group M.
@en
Impaired FANCD2 monoubiquitina ...... nemia complementation group M.
@nl
P2093
P2860
P1433
P1476
Impaired FANCD2 monoubiquitina ...... nemia complementation group M.
@en
P2093
Abdullah Mahmood Ali
Amom Ruhikanta Meetei
Barbara C Godthelp
Chang-hu Du
David A Williams
Elke Grassman
Hans Joenje
Johan P de Winter
Jurgen Steltenpool
Kebola Wahengbam
P2860
P304
P356
10.1182/BLOOD-2009-02-207811
P407
P577
2009-05-07T00:00:00Z