Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance
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Cellular ageing mechanisms in osteoarthritisChondrocyte Apoptosis in the Pathogenesis of OsteoarthritisEpigenetic Regulation of Chondrocyte Catabolism and Anabolism in OsteoarthritisAn overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial jointsMetabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-AnalysisMitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degenerationThe beneficial effects of exercise on cartilage are lost in mice with reduced levels of ECSOD in tissuesBach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways.Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytesAutophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritisAnalysis of synovial fluid in knee joint of osteoarthritis:5 proteome patterns of joint inflammation based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Comprehensive profiling of cartilage extracellular matrix formation and maturation using sequential extraction and label-free quantitative proteomics.Hsp90β inhibition modulates nitric oxide production and nitric oxide-induced apoptosis in human chondrocytesAge-related changes in the musculoskeletal system and the development of osteoarthritis.Global metabolic profiling of human osteoarthritic synovium.Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis.Pharmacoproteomic study of three different chondroitin sulfate compounds on intracellular and extracellular human chondrocyte proteomes.The potential of multiple synovial-fluid protein-concentration analyses in the assessment of knee osteoarthritis.Mitochondrial respiratory chain dysfunction modulates metalloproteases -1, -3 and -13 in human normal chondrocytes in culture.Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty AcidsLabel-free protein profiling of adipose-derived human stem cells under hyperosmotic treatment.Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes.Mitochondrial respiration and redox coupling in articular chondrocytesApplication for proteomic techniques in studying osteoarthritis: a reviewEupatilin Exerts Antinociceptive and Chondroprotective Properties in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in ChondrocytesMechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration.Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis.Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.Mitochondrial electron transport and glycolysis are coupled in articular cartilage.Synovium and the innate inflammatory network in osteoarthritis progression.Therapeutic effects of the superoxide dismutase mimetic compound MnIIMe2DO2A on experimental articular pain in rats.Ageing and the pathogenesis of osteoarthritis.Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease.The future of osteoarthritis therapeutics: targeted pharmacological therapyAging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix.Cartilage homeostasis in health and rheumatic diseases.A straightforward and highly efficient precipitation/on-pellet digestion procedure coupled with a long gradient nano-LC separation and Orbitrap mass spectrometry for label-free expression profiling of the swine heart mitochondrial proteome.Quantitative proteomics reveals regulatory differences in the chondrocyte secretome from human medial and lateral femoral condyles in osteoarthritic patientsInducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury.
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Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 09 September 2008
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Mitochondrial dysregulation of ...... se points to a redox imbalance
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Mitochondrial dysregulation of ...... e points to a redox imbalance.
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type
label
Mitochondrial dysregulation of ...... se points to a redox imbalance
@en
Mitochondrial dysregulation of ...... e points to a redox imbalance.
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prefLabel
Mitochondrial dysregulation of ...... se points to a redox imbalance
@en
Mitochondrial dysregulation of ...... e points to a redox imbalance.
@nl
P2093
P2860
P50
P1476
Mitochondrial dysregulation of ...... se points to a redox imbalance
@en
P2093
Francisco J Blanco
Mercedes Fernández
Montserrat Martínez-Gomariz
Vanessa Carreira
P2860
P304
P356
10.1074/MCP.M800292-MCP200
P577
2008-09-09T00:00:00Z