Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance - Wikidata - wikimedia - TriplyDB

Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance

Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance

http://www.wikidata.org/entity/Q37267822

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Cellular ageing mechanisms in osteoarthritis Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis Epigenetic Regulation of Chondrocyte Catabolism and Anabolism in Osteoarthritis An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration The beneficial effects of exercise on cartilage are lost in mice with reduced levels of ECSOD in tissues Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1 Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways.Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytes Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis Analysis of synovial fluid in knee joint of osteoarthritis:5 proteome patterns of joint inflammation based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Comprehensive profiling of cartilage extracellular matrix formation and maturation using sequential extraction and label-free quantitative proteomics.Hsp90β inhibition modulates nitric oxide production and nitric oxide-induced apoptosis in human chondrocytes Age-related changes in the musculoskeletal system and the development of osteoarthritis.Global metabolic profiling of human osteoarthritic synovium.Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis.Pharmacoproteomic study of three different chondroitin sulfate compounds on intracellular and extracellular human chondrocyte proteomes.The potential of multiple synovial-fluid protein-concentration analyses in the assessment of knee osteoarthritis.Mitochondrial respiratory chain dysfunction modulates metalloproteases -1, -3 and -13 in human normal chondrocytes in culture.Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids Label-free protein profiling of adipose-derived human stem cells under hyperosmotic treatment.Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes.Mitochondrial respiration and redox coupling in articular chondrocytes Application for proteomic techniques in studying osteoarthritis: a review Eupatilin Exerts Antinociceptive and Chondroprotective Properties in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration.Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis.Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.Mitochondrial electron transport and glycolysis are coupled in articular cartilage.Synovium and the innate inflammatory network in osteoarthritis progression.Therapeutic effects of the superoxide dismutase mimetic compound MnIIMe2DO2A on experimental articular pain in rats.Ageing and the pathogenesis of osteoarthritis.Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease.The future of osteoarthritis therapeutics: targeted pharmacological therapy Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix.Cartilage homeostasis in health and rheumatic diseases.A straightforward and highly efficient precipitation/on-pellet digestion procedure coupled with a long gradient nano-LC separation and Orbitrap mass spectrometry for label-free expression profiling of the swine heart mitochondrial proteome.Quantitative proteomics reveals regulatory differences in the chondrocyte secretome from human medial and lateral femoral condyles in osteoarthritic patients Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury.

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Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance

http://www.wikidata.org/entity/Q37267822

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bilimsel makale

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scientific article published on 09 September 2008

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Molecular & Cellular Proteomics

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Mitochondrial dysregulation of ...... se points to a redox imbalance

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Francisco J Blanco

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Mercedes Fernández

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Montserrat Martínez-Gomariz

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Vanessa Carreira

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P2860

Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

The mitochondrial inner membrane protein mitofilin controls cristae morphology

Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function.

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Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

Difference gel electrophoresis: a single gel method for detecting changes in protein extracts

Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

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1

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8

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Cristina Ruiz-Romero

Valentina Calamia

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2008-09-09T00:00:00Z

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23249726

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