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The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerPathways governing G1/S transition and their response to DNA damageThe role of Cdc25A in the regulation of cell proliferation and apoptosisRegulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stabilityBioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer.Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 bindingTargeting PTPs with small molecule inhibitors in cancer treatmentOverexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypesTransforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism.LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation.Multifaceted regulation of cell cycle progression by estrogen: regulation of Cdk inhibitors and Cdc25A independent of cyclin D1-Cdk4 functionA novel mechanism of indole-3-carbinol effects on breast carcinogenesis involves induction of Cdc25A degradationAnti-CDC25B autoantibody predicts poor prognosis in patients with advanced esophageal squamous cell carcinoma.Human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest.A bioinformatics-based strategy identifies c-Myc and Cdc25A as candidates for the Apmt mammary tumor latency modifiersCdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis.K vitamins, PTP antagonism, and cell growth arrest.Dual-specificity phosphatases as targets for antineoplastic agents.Cdc25A regulates matrix metalloprotease 1 through Foxo1 and mediates metastasis of breast cancer cells.Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis.Screening of indeno[1,2-b]indoloquinones by MALDI-MS: a new set of potential CDC25 phosphatase inhibitors brought to light.MicroRNA-215 Regulates Fibroblast Function: Insights from a Human Fibrotic Disease.Targeting the PTPome in human disease.GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.Cyclin A is a prognostic indicator in early stage breast cancer with and without tamoxifen treatment.CDC25A protein stability represents a previously unrecognized target of HER2 signaling in human breast cancer: implication for a potential clinical relevance in trastuzumab treatment.Phosphatases and kinases regulating CDC25 activity in the cell cycle: clinical implications of CDC25 overexpression and potential treatment strategiesMicroarray and pathway analysis reveals decreased CDC25A and increased CDC42 associated with slow growth of BCL2 overexpressing immortalized breast cell line.Overexpression of CDC25B and LAMC2 mRNA and protein in esophageal squamous cell carcinomas and premalignant lesions in subjects from a high-risk population in China.Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias.SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways.Inhibitors of Cdc25 phosphatases as anticancer agents: a patent review.The regulatory roles of phosphatases in cancer.Dissection of the oncogenic MYCN transcriptional network reveals a large set of clinically relevant cell cycle genes as drivers of neuroblastoma tumorigenesis.Non-malignant and tumor-derived cells differ in their requirement for p27Kip1 in transforming growth factor-beta-mediated G1 arrest.Role of Forkhead Box Class O proteins in cancer progression and metastasis.miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2000
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Role of the Cdc25A phosphatase in human breast cancer
@en
Role of the Cdc25A phosphatase in human breast cancer.
@nl
type
label
Role of the Cdc25A phosphatase in human breast cancer
@en
Role of the Cdc25A phosphatase in human breast cancer.
@nl
prefLabel
Role of the Cdc25A phosphatase in human breast cancer
@en
Role of the Cdc25A phosphatase in human breast cancer.
@nl
P2093
P2860
P356
P1476
Role of the Cdc25A phosphatase in human breast cancer
@en
P2093
M Ranashinge
S Signoretti
P2860
P304
P356
10.1172/JCI9174
P407
P577
2000-09-01T00:00:00Z