DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo
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Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic CellsGuanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cellsNucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus.Optimal oligonucleotide sequences for TLR9 inhibitory activity in human cells: lack of correlation with TLR9 bindingFcγRIIB regulation of BCR/TLR-dependent autoreactive B-cell responsesAggregation and secondary loop structure of oligonucleotides do not determine their ability to inhibit TLR9Nucleic acid-binding polymers as anti-inflammatory agentsImmunomodulatory spherical nucleic acids.Mdm2 promotes systemic lupus erythematosus and lupus nephritisMyeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onsetB cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice.Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9.Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation.Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9.Nuclease deficiencies promote end-stage lupus nephritis but not nephritogenic autoimmunity in (NZB × NZW) F1 mice.Toll-like receptor driven B cell activation in the induction of systemic autoimmunity.Modulating toll-like receptor 7 and 9 responses as therapy for allergy and autoimmunity.A novel pathogenetic concept-antiviral immunity in lupus nephritis.5'-Phosphate oligodeoxynucleotides enhance the phosphodiester-CpG DNA-induced inflammatory response in macrophages.Inhibitory short synthetic oligodeoxynucleotides and lupus.The potential importance of Toll-like receptors in ankylosing spondylitis.Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses.A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice.Abnormal thymic maturation and lymphoproliferation in MRL-Fas lpr/lpr mice can be partially reversed by synthetic oligonucleotides: implications for systemic lupus erythematosus and autoimmune lymphoproliferative syndrome.Engagement of the B cell receptor for antigen differentially affects B cell responses to Toll-like receptor-7 agonists and antagonists in BXSB mice.Oligodeoxynucleotide inhibition of Toll-like receptors 3, 7, 8, and 9 suppresses cytokine production in a human rheumatoid arthritis model.B-cell receptor for antigen modulates B-cell responses to complex TLR9 agonists and antagonists: implications for systemic lupus erythematosus.Patent highlights August-September 2016.
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P2860
DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
DNA-like class R inhibitory ol ...... MRL-Fas(lpr/lpr) mice in vivo
@en
DNA-like class R inhibitory oligonucleotides
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type
label
DNA-like class R inhibitory ol ...... MRL-Fas(lpr/lpr) mice in vivo
@en
DNA-like class R inhibitory oligonucleotides
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prefLabel
DNA-like class R inhibitory ol ...... MRL-Fas(lpr/lpr) mice in vivo
@en
DNA-like class R inhibitory oligonucleotides
@nl
P2093
P2860
P50
P356
P1476
DNA-like class R inhibitory ol ...... MRL-Fas(lpr/lpr) mice in vivo
@en
P2093
Ann Marshak-Rothstein
Courtney Fleenor
Liliana Busconi
Patrice Nelson
Petar Lenert
Radhika S Ratnabalasuriar
Robert F Ashman
P2860
P2888
P356
10.1186/AR2710
P577
2009-05-28T00:00:00Z
P5875
P6179
1027911850