Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection.
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Nonhuman primate models for HIV/AIDS vaccine developmentGagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivoTCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeysStructural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responsesT-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targetingαβ T cell receptors as predictors of health and diseaseIdentification of a CD4 T-cell epitope in the hemagglutinin stalk domain of pandemic H1N1 influenza virus and its antigen-driven TCR usage signature in BALB/c miceVaccine design for CD8 T lymphocyte responsesGeneration of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes.Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques.Public TCR use by herpes simplex virus-2-specific human CD8 CTLs.Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infectionNovel recombinant Mycobacterium bovis BCG, ovine atadenovirus, and modified vaccinia virus Ankara vaccines combine to induce robust human immunodeficiency virus-specific CD4 and CD8 T-cell responses in rhesus macaquesDiversity of the CD8+ T cell repertoire elicited against an immunodominant epitope does not depend on the context of infection.Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parametersNegative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection.Peptide-MHC class II complex stability governs CD4 T cell clonal selection.Surface expression of MPT64 as a fusion with the PE domain of PE_PGRS33 enhances Mycobacterium bovis BCG protective activity against Mycobacterium tuberculosis in miceConvergent recombination shapes the clonotypic landscape of the naive T-cell repertoire.Profile of a serial killer: cellular and molecular approaches to study individual cytotoxic T-cells following therapeutic vaccination.Paired analysis of TCRα and TCRβ chains at the single-cell level in mice.Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.Immune mechanisms of HIV control.Simian immunodeficiency virus SIVmac239Deltanef vaccination elicits different Tat28-35SL8-specific CD8+ T-cell clonotypes compared to a DNA prime/adenovirus type 5 boost regimen in rhesus macaques.Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infectionAcute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responses.Persistence of EBV antigen-specific CD8 T cell clonotypes during homeostatic immune reconstitution in cancer patients.Unbiased molecular analysis of T cell receptor expression using template-switch anchored RT-PCREscape from highly effective public CD8+ T-cell clonotypes by HIVHigh-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV controlCharacterization of an effective CTL response against HIV and SIV infections.CD8+ TCR Bias and Immunodominance in HIV-1 Infection.Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacityHLA B*5701-positive long-term nonprogressors/elite controllers are not distinguished from progressors by the clonal composition of HIV-specific CD8+ T cells.Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamicsVirus inhibition activity of effector memory CD8(+) T cells determines simian immunodeficiency virus load in vaccinated monkeys after vaccine breakthrough infection.Determinants of public T cell responses.β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure.Expansion of Simian Immunodeficiency Virus (SIV)-Specific CD8 T Cell Lines from SIV-Naive Mauritian Cynomolgus Macaques for Adoptive Transfer.A TCR affinity threshold regulates memory CD4 T cell differentiation following vaccination.
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Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 06 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Public clonotype usage identif ...... ll responses in SIV infection.
@en
Public clonotype usage identif ...... ll responses in SIV infection.
@nl
type
label
Public clonotype usage identif ...... ll responses in SIV infection.
@en
Public clonotype usage identif ...... ll responses in SIV infection.
@nl
prefLabel
Public clonotype usage identif ...... ll responses in SIV infection.
@en
Public clonotype usage identif ...... ll responses in SIV infection.
@nl
P2093
P2860
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P356
P1476
Public clonotype usage identif ...... ll responses in SIV infection.
@en
P2093
Daniel C Douek
Emma Gostick
Ian S Metzler
Jason M Brenchley
Mario Roederer
Martha C Nason
Nancy A Wilson
Tedi E Asher
Vanessa Venturi
P2860
P304
P356
10.1084/JEM.20081127
P407
P577
2009-04-06T00:00:00Z