Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection. - Wikidata - wikimedia - TriplyDB

Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection.

Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection.

http://www.wikidata.org/entity/Q37273289

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Nonhuman primate models for HIV/AIDS vaccine development GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeys Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting αβ T cell receptors as predictors of health and disease Identification of a CD4 T-cell epitope in the hemagglutinin stalk domain of pandemic H1N1 influenza virus and its antigen-driven TCR usage signature in BALB/c mice Vaccine design for CD8 T lymphocyte responses Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes.Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques.Public TCR use by herpes simplex virus-2-specific human CD8 CTLs.Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection Novel recombinant Mycobacterium bovis BCG, ovine atadenovirus, and modified vaccinia virus Ankara vaccines combine to induce robust human immunodeficiency virus-specific CD4 and CD8 T-cell responses in rhesus macaques Diversity of the CD8+ T cell repertoire elicited against an immunodominant epitope does not depend on the context of infection.Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection.Peptide-MHC class II complex stability governs CD4 T cell clonal selection.Surface expression of MPT64 as a fusion with the PE domain of PE_PGRS33 enhances Mycobacterium bovis BCG protective activity against Mycobacterium tuberculosis in mice Convergent recombination shapes the clonotypic landscape of the naive T-cell repertoire.Profile of a serial killer: cellular and molecular approaches to study individual cytotoxic T-cells following therapeutic vaccination.Paired analysis of TCRα and TCRβ chains at the single-cell level in mice.Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.Immune mechanisms of HIV control.Simian immunodeficiency virus SIVmac239Deltanef vaccination elicits different Tat28-35SL8-specific CD8+ T-cell clonotypes compared to a DNA prime/adenovirus type 5 boost regimen in rhesus macaques.Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection Acute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responses.Persistence of EBV antigen-specific CD8 T cell clonotypes during homeostatic immune reconstitution in cancer patients.Unbiased molecular analysis of T cell receptor expression using template-switch anchored RT-PCR Escape from highly effective public CD8+ T-cell clonotypes by HIV High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control Characterization of an effective CTL response against HIV and SIV infections.CD8+ TCR Bias and Immunodominance in HIV-1 Infection.Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity HLA B*5701-positive long-term nonprogressors/elite controllers are not distinguished from progressors by the clonal composition of HIV-specific CD8+ T cells.Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics Virus inhibition activity of effector memory CD8(+) T cells determines simian immunodeficiency virus load in vaccinated monkeys after vaccine breakthrough infection.Determinants of public T cell responses.β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure.Expansion of Simian Immunodeficiency Virus (SIV)-Specific CD8 T Cell Lines from SIV-Naive Mauritian Cynomolgus Macaques for Adoptive Transfer.A TCR affinity threshold regulates memory CD4 T cell differentiation following vaccination.

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Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection.

http://www.wikidata.org/entity/Q37273289

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article científic

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article scientifique

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artigo científico

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bilimsel makale

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scientific article published on 06 April 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Public clonotype usage identif ...... ll responses in SIV infection.

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Public clonotype usage identif ...... ll responses in SIV infection.

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Public clonotype usage identif ...... ll responses in SIV infection.

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Public clonotype usage identif ...... ll responses in SIV infection.

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Public clonotype usage identif ...... ll responses in SIV infection.

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Public clonotype usage identif ...... ll responses in SIV infection.

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Journal of Experimental Medicine

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Public clonotype usage identif ...... ll responses in SIV infection.

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Daniel C Douek

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Emma Gostick

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Ian S Metzler

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Jason M Brenchley

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Mario Roederer

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Martha C Nason

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Nancy A Wilson

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Tedi E Asher

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Vanessa Venturi

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CDR3 loop flexibility contributes to the degeneracy of TCR recognition

First glimpse of the peptide presentation by rhesus macaque MHC class I: crystal structures of Mamu-A*01 complexed with two immunogenic SIV epitopes and insights into CTL escape

Epitope-specific TCR repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

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CD8(+) lymphocytes from simian immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule mamu-A*01: implications for vaccine design and testing.

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10.1084/JEM.20081127

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Pratip K. Chattopadhyay

Miles P Davenport

David I Watkins

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