Impairment of ubiquitylation by mutation in Drosophila E1 promotes both cell-autonomous and non-cell-autonomous Ras-ERK activation in vivo
about
Dpp-induced Egfr signaling triggers postembryonic wing development in Drosophila.Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events.Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila.When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling.Ras/MAPK signaling from endomembranesMutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment.Ubiquitin on ras: warden or partner in crime?Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitinationCRL Ubiquitin Ligases and DNA Damage Response.Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.
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Impairment of ubiquitylation by mutation in Drosophila E1 promotes both cell-autonomous and non-cell-autonomous Ras-ERK activation in vivo
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 14 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Impairment of ubiquitylation b ...... ous Ras-ERK activation in vivo
@en
Impairment of ubiquitylation b ...... us Ras-ERK activation in vivo.
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type
label
Impairment of ubiquitylation b ...... ous Ras-ERK activation in vivo
@en
Impairment of ubiquitylation b ...... us Ras-ERK activation in vivo.
@nl
prefLabel
Impairment of ubiquitylation b ...... ous Ras-ERK activation in vivo
@en
Impairment of ubiquitylation b ...... us Ras-ERK activation in vivo.
@nl
P2093
P2860
P356
P1476
Impairment of ubiquitylation b ...... ous Ras-ERK activation in vivo
@en
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Cathie M Pfleger
Elizabeth A Horvath
Elizabeth A Kane
Mei-Ling Chin
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P304
P356
10.1242/JCS.042267
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P577
2009-04-14T00:00:00Z