Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging.
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The quiescent cellular state is Arf/p53-dependent and associated with H2AX downregulation and genome stabilityPostnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration.Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression.New biomarkers probing depth of cell senescence assessed by laser scanning cytometry.Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status.Four faces of cellular senescence.Inflammation and p53: A Tale of Two StressesImpaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient miceCombined activation of the energy and cellular-defense pathways may explain the potent anti-senescence activity of methylene blue.Metabolic regulation by p53 family members.Using mice to examine p53 functions in cancer, aging, and longevity.Apoptosis and aging: increased resistance to apoptosis enhances the aging process.Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype.Insights into wild-type and mutant p53 functions provided by genetically engineered mice.BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance.p53 and the Carcinogenicity of Chronic Inflammation.Modification of the alkaline comet assay with human mesenchymal stem cells.Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosisCdkn1b overexpression in adult mice alters the balance between genome and tissue ageing.Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice.
P2860
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P2860
Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging.
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Altered senescence, apoptosis, ...... 53 model of accelerated aging.
@en
Altered senescence, apoptosis, ...... 53 model of accelerated aging.
@nl
type
label
Altered senescence, apoptosis, ...... 53 model of accelerated aging.
@en
Altered senescence, apoptosis, ...... 53 model of accelerated aging.
@nl
prefLabel
Altered senescence, apoptosis, ...... 53 model of accelerated aging.
@en
Altered senescence, apoptosis, ...... 53 model of accelerated aging.
@nl
P2093
P2860
P1476
Altered senescence, apoptosis, ...... 53 model of accelerated aging.
@en
P2093
Catherine E Gatza
George W Hinkal
Lawrence A Donehower
Neha Parikh
P2860
P304
P356
10.1016/J.MAD.2009.01.001
P577
2009-04-01T00:00:00Z