Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression.
about
Unbalanced replication as a major source of genetic instability in cancer cellsIrradiation selects for p53-deficient hematopoietic progenitors.The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expressionImpact papers on aging in 2009.In vivo analysis of p53 tumor suppressor function using genetically engineered mouse modelsThe p53 network: cellular and systemic DNA damage responses in aging and cancer.Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape.Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis.Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection?Low-dose arsenic induces chemotherapy protection via p53/NF-κB-mediated metabolic regulation.Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphomaTumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes.Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- miceThe p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.Impaired mitochondrial metabolism and mammary carcinogenesisp19(Arf) is required for the cellular response to chronic DNA damagep53-dependent delayed effects of radiation vary according to time of irradiation of p53 + / - mice.Using mice to examine p53 functions in cancer, aging, and longevity.Deconstructing p53 transcriptional networks in tumor suppression.Illuminating p53 function in cancer with genetically engineered mouse models.Insights into wild-type and mutant p53 functions provided by genetically engineered mice.Unravelling mechanisms of p53-mediated tumour suppression.Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines).The role of DNA damage responses in p53 biology.Sustained p16INK4a expression is required to prevent IR-induced tumorigenesis in miceDNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging.Deciphering p53 signaling in tumor suppression.Deconstructing networks of p53-mediated tumor suppression in vivo.
P2860
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P2860
Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression.
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Timed somatic deletion of p53 ...... ferences in tumor progression.
@ast
Timed somatic deletion of p53 ...... ferences in tumor progression.
@en
type
label
Timed somatic deletion of p53 ...... ferences in tumor progression.
@ast
Timed somatic deletion of p53 ...... ferences in tumor progression.
@en
prefLabel
Timed somatic deletion of p53 ...... ferences in tumor progression.
@ast
Timed somatic deletion of p53 ...... ferences in tumor progression.
@en
P2093
P2860
P1433
P1476
Timed somatic deletion of p53 ...... ferences in tumor progression.
@en
P2093
George Hinkal
Lawrence A Donehower
Neha Parikh
P2860
P356
10.1371/JOURNAL.PONE.0006654
P407
P577
2009-08-14T00:00:00Z