Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear.
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Molecular mechanisms of inner ear developmentScanning thin-sheet laser imaging microscopy elucidates details on mouse ear development.EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner earSipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial developmentDlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesisConditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epitheliumThe molecular basis of making spiral ganglion neurons and connecting them to hair cells of the organ of CortiDissecting the molecular basis of organ of Corti development: Where are we now?Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of CortiEvolving gene regulatory networks into cellular networks guiding adaptive behavior: an outline how single cells could have evolved into a centralized neurosensory system.Connecting the ear to the brain: Molecular mechanisms of auditory circuit assembly.Redundant functions of Rac GTPases in inner ear morphogenesisUnderstanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation.The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear.Hair cell fate decisions in cochlear development and regenerationResidual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice.EYA1 mutations associated with the branchio-oto-renal syndrome result in defective otic development in Xenopus laevisBuilding the world's best hearing aid; regulation of cell fate in the cochleaA focused in situ hybridization screen identifies candidate transcriptional regulators of thymic epithelial cell development and function.A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability.Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung.Continued expression of GATA3 is necessary for cochlear neurosensory developmentHMGA2, the architectural transcription factor high mobility group, is expressed in the developing and mature mouse cochlea.The Eyes Absent proteins in development and disease.The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition.Dissecting the pre-placodal transcriptome to reveal presumptive direct targets of Six1 and Eya1 in cranial placodes.Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition.Progression of neurogenesis in the inner ear requires inhibition of Sox2 transcription by neurogenin1 and neurod1.Specification of cell fate in the mammalian cochleaThe role of bHLH genes in ear development and evolution: revisiting a 10-year-old hypothesis.The convergence of cochlear implantation with induced pluripotent stem cell therapy.Culture conditions have an impact on the maturation of traceable, transplantable mouse embryonic stem cell-derived otic progenitor cells.Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium.Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2.Canonical Wnt signaling modulates Tbx1, Eya1, and Six1 expression, restricting neurogenesis in the otic vesicle.Eya1 interacts with Six2 and Myc to regulate expansion of the nephron progenitor pool during nephrogenesis.Differential and overlapping expression pattern of SOX2 and SOX9 in inner ear development.The role of sensory organs and the forebrain for the development of the craniofacial shape as revealed by Foxg1-cre-mediated microRNA loss.Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung.
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Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 04 August 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Eya1 gene dosage critically af ...... ia in the mammalian inner ear.
@en
Eya1 gene dosage critically af ...... ia in the mammalian inner ear.
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type
label
Eya1 gene dosage critically af ...... ia in the mammalian inner ear.
@en
Eya1 gene dosage critically af ...... ia in the mammalian inner ear.
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prefLabel
Eya1 gene dosage critically af ...... ia in the mammalian inner ear.
@en
Eya1 gene dosage critically af ...... ia in the mammalian inner ear.
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P2093
P2860
P356
P1476
Eya1 gene dosage critically af ...... ia in the mammalian inner ear.
@en
P2093
Christopher Erickson
Dongzhu Jin
Eun-Hee Kim
Pin-Xian Xu
P2860
P304
P356
10.1093/HMG/DDN229
P577
2008-08-04T00:00:00Z