Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia.
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Acute lymphoblastic leukaemiaJAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indicationsGenomic profiling of B-progenitor acute lymphoblastic leukemiaStructure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibitionHematological disorders and leukemia in children with Down syndrome.Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.The Eleventh International Childhood Acute Lymphoblastic Leukemia Workshop Report: Ponte di Legno, Italy, 6-7 May 2009.The biology, pathogenesis and clinical aspects of acute lymphoblastic leukemia in children with Down syndrome.Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profilesA Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition.Down syndrome childhood acute lymphoblastic leukemia has a unique spectrum of sentinel cytogenetic lesions that influences treatment outcome: a report from the Children's Oncology GroupCRLF2 and JAK2 in B-progenitor acute lymphoblastic leukemia: a novel association in oncogenesis.IL-7 in human health and disease.Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening.Understanding the biology of CRLF2-overexpressing acute lymphoblastic leukemiaIn search of targeted therapies for childhood cancer.Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia.Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?JAK Kinases in Health and Disease: An UpdateContribution of JAK2 mutations to T-cell lymphoblastic lymphoma development.Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21.Constitutional aneuploidy and cancer predisposition.Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group.Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinasesGenomic profiling of high-risk acute lymphoblastic leukemia.A structure-function perspective of Jak2 mutations and implications for alternate drug design strategies: the road not taken.Acute lymphoblastic leukaemia in children with Down syndrome: an updated review.JAK2 inhibition for the treatment of hematologic and solid malignancies.Pediatric relapsed or refractory leukemia: new pharmacotherapeutic developments and future directions.Genomics in acute lymphoblastic leukaemia: insights and treatment implications.Activation of the Janus kinase/signal transducer and activator of transcription pathway in multiple myeloma is not related to point mutations in kinase and pseudokinase domains of JAK1.The promise of Janus kinase inhibitors in the treatment of hematological malignancies.Philadelphia chromosome-like acute lymphoblastic leukemia.Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia.Outcomes of treatment for relapsed acute lymphoblastic leukaemia in children with Down syndrome.Chronic lymphocytic leukemia presenting as an intracranial epidural mass in a patient with myeloproliferative neoplasm associated with JAK2 V617F mutation.Acute lymphoblastic leukemia and Down syndrome: the collaborative study of the Tokyo Children's Cancer Study Group and the Kyushu Yamaguchi Children's Cancer Study Group.Gene alterations involving the CRLF2-JAK pathway and recurrent gene deletions in Down syndrome-associated acute lymphoblastic leukemia in Japan.Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia.
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Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 20 December 2008
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vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Prevalence and clinical correl ...... acute lymphoblastic leukaemia.
@en
Prevalence and clinical correl ...... acute lymphoblastic leukaemia.
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type
label
Prevalence and clinical correl ...... acute lymphoblastic leukaemia.
@en
Prevalence and clinical correl ...... acute lymphoblastic leukaemia.
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prefLabel
Prevalence and clinical correl ...... acute lymphoblastic leukaemia.
@en
Prevalence and clinical correl ...... acute lymphoblastic leukaemia.
@nl
P2093
P2860
P50
P1476
Prevalence and clinical correl ...... acute lymphoblastic leukaemia
@en
P2093
Amos Gaikwad
Andrew J Carroll
Cassia L Rye
Karen R Rabin
Meenakshi Devidas
Shai Izraeli
Sharon E Plon
P2860
P304
P356
10.1111/J.1365-2141.2008.07552.X
P407
P577
2008-12-20T00:00:00Z