OX40 drives protective vaccinia virus-specific CD8 T cells. - Wikidata - wikimedia - TriplyDB

OX40 drives protective vaccinia virus-specific CD8 T cells.

OX40 drives protective vaccinia virus-specific CD8 T cells.

http://www.wikidata.org/entity/Q37311042

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Science gone translational: the OX40 agonist story CD8 T cells use IFN-γ to protect against the lethal effects of a respiratory poxvirus infection.Control of immunity by the TNFR-related molecule OX40 (CD134)OX40 facilitates control of a persistent virus infection.The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice A stimulating way to improve T cell responses to poxvirus-vectored vaccines Regulation of A1 by OX40 contributes to CD8(+) T cell survival and anti-tumor activity.B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus.The significance of OX40 and OX40L to T-cell biology and immune disease.CD8 T cell memory to a viral pathogen requires trans cosignaling between HVEM and BTLA.Targeting OX40 promotes lung-resident memory CD8 T cell populations that protect against respiratory poxvirus infection Preferential replication of vaccinia virus in the ovaries is independent of immune regulation through IL-10 and TGF-β Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation.Activation of OX40 prolongs and exacerbates autoimmune experimental uveitis Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity.Dispensable role for 4-1BB and 4-1BBL in development of vaccinia virus-specific CD8 T cells An alternative signal 3: CD8⁺ T cell memory independent of IL-12 and type I IFN is dependent on CD27/OX40 signaling.Combined mTOR inhibition and OX40 agonism enhances CD8(+) T cell memory and protective immunity produced by recombinant adenovirus vaccines Extent of Systemic Spread Determines CD8+ T Cell Immunodominance for Laboratory Strains, Smallpox Vaccines, and Zoonotic Isolates of Vaccinia Virus.Targeting 4-1BB (CD137) to enhance CD8 T cell responses with poxviruses and viral antigens.CD8 T cells are essential for recovery from a respiratory vaccinia virus infection.Natural Killer Cells and Innate Interferon Gamma Participate in the Host Defense against Respiratory Vaccinia Virus Infection.C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection.The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria.The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood.The adaptor molecule MyD88 directly promotes CD8 T cell responses to vaccinia virus.Transcription Factor Bcl11b Controls Effector and Memory CD8 T cell Fate Decision and Function during Poxvirus Infection High frequencies of virus-specific CD8+ T-cell precursors.Tissue-specific programming of memory CD8 T cell subsets impacts protection against lethal respiratory virus infection.The role of OX40-mediated co-stimulation in T-cell activation and survival.Costimulation signals for memory CD8+ T cells during viral infections.Tumor necrosis factor receptor/tumor necrosis factor family members in antiviral CD8 T-cell immunity.OX40:OX40L axis: emerging targets for improving poxvirus-based CD8(+) T-cell vaccines against respiratory viruses Tumor-infiltrating lymphocyte therapy for melanoma: rationale and issues for further clinical development.OX40, OX40L and Autoimmunity: a Comprehensive Review.Melanoma Immunotherapy in Mice Using Genetically Engineered Pluripotent Stem Cells.HVEM Imprints Memory Potential on Effector CD8 T Cells Required for Protective Mucosal Immunity.OX40 Cooperates with ICOS To Amplify Follicular Th Cell Development and Germinal Center Reactions during Infection.

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OX40 drives protective vaccinia virus-specific CD8 T cells.

http://www.wikidata.org/entity/Q37311042

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on December 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

OX40 drives protective vaccinia virus-specific CD8 T cells.

@en

OX40 drives protective vaccinia virus-specific CD8 T cells.

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type

label

OX40 drives protective vaccinia virus-specific CD8 T cells.

@en

OX40 drives protective vaccinia virus-specific CD8 T cells.

@nl

prefLabel

OX40 drives protective vaccinia virus-specific CD8 T cells.

@en

OX40 drives protective vaccinia virus-specific CD8 T cells.

@nl

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JIMMUNOL.181.11.7969

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Journal of Immunology

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OX40 drives protective vaccinia virus-specific CD8 T cells.

@en

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Magdalini Moutaftsi

http://www.w3.org/2001/XMLSchema#string

Michael Croft

http://www.w3.org/2001/XMLSchema#string

Shahram Salek-Ardakani

http://www.w3.org/2001/XMLSchema#string

Shane Crotty

http://www.w3.org/2001/XMLSchema#string

P2860

OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

The costimulation-regulated duration of PKB activation controls T cell longevity

Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion

Protection against lethal vaccinia virus challenge in HLA-A2 transgenic mice by immunization with a single CD8+ T-cell peptide epitope of vaccinia and variola viruses.

Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines

Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice.

Combinations of polyclonal or monoclonal antibodies to proteins of the outer membranes of the two infectious forms of vaccinia virus protect mice against a lethal respiratory challenge

Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines.

A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus.

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7969-7976

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scholarly article

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10.4049/JIMMUNOL.181.11.7969

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11

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Alessandro Sette

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2008-12-01T00:00:00Z

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23482213

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19017988

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2729132

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