Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma.
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PRIMA-1(MET) induces death in soft-tissue sarcomas cell independent of p53.Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine.PRIMA-1MET induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial ovarian cancer cells2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells.Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulationThe importance of being dead: cell death mechanisms assessment in anti-sarcoma therapy.Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer.Sensitivity to PRIMA-1MET is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 statusAPR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma.PRIMA-1Met induces apoptosis in Waldenström's Macroglobulinemia cells independent of p53.PRIMA-1 and PRIMA-1Met (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial Therapies.Potential therapeutic targets of TP53 gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer.
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Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Variability in functional p53 reactivation by PRIMA-1
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Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma.
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Variability in functional p53 reactivation by PRIMA-1
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Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma.
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prefLabel
Variability in functional p53 reactivation by PRIMA-1
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Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma.
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P2093
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Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma
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D N T Aryee
K Muehlbacher
R Schwentner
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P2888
P304
P356
10.1038/BJC.2013.635
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P577
2013-10-15T00:00:00Z