Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. - Wikidata - wikimedia - TriplyDB

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.

http://www.wikidata.org/entity/Q37331580

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Rho, ROCK and actomyosin contractility in metastasis as drug targets The myofibroblast in wound healing and fibrosis: answered and unanswered questions Collective cell migration in development Non-muscle myosin II in disease: mechanisms and therapeutic opportunities Direct Interaction between Carcinoma Cells and Cancer Associated Fibroblasts for the Regulation of Cancer Invasion MST kinases in development and disease The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis Cancer-associated fibroblasts in digestive tumors Rho GTPases in collective cell migration Mesenchymal Stem Cells Induce Directional Migration of Invasive Breast Cancer Cells through TGF-β ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion.Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells Tension in Cancer The Borg family of Cdc42 effector proteins Cdc42EP1-5 Membrane-to-Nucleus Signals and Epigenetic Mechanisms for Myofibroblastic Activation and Desmoplastic Stroma: Potential Therapeutic Targets for Liver Metastasis?Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-β-induced cancer-associated fibroblast differentiation Impact of the physical microenvironment on tumor progression and metastasis Microenvironmental regulation of tumor progression and metastasis The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture.Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.Shear-wave elasticity measurements of three-dimensional cell cultures for mechanobiology A rapid co-culture stamping device for studying intercellular communication YAP regulates cell mechanics by controlling focal adhesion assembly.Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells MDP, a database linking drug response data to genomic information, identifies dasatinib and statins as a combinatorial strategy to inhibit YAP/TAZ in cancer cells Framework to function: mechanosensitive regulators of gene transcription Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells Macroscopic stiffness of breast tumors predicts metastasis.Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex The hippo pathway in heart development, regeneration, and diseases Dendritic cells control fibroblastic reticular network tension and lymph node expansion.Integrin αv in the mechanical response of osteoblast lineage cells.TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.Hypoxia and the extracellular matrix: drivers of tumour metastasis Pharmacological activation of myosin II paralogs to correct cell mechanics defects.Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition.Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells Dynamic stiffening of poly(ethylene glycol)-based hydrogels to direct valvular interstitial cell phenotype in a three-dimensional environment.Three-dimensional organotypic culture: experimental models of mammalian biology and disease.

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Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.

http://www.wikidata.org/entity/Q37331580

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 26 May 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Mechanotransduction and YAP-de ...... cancer-associated fibroblasts.

@en

Mechanotransduction and YAP-de ...... cancer-associated fibroblasts.

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type

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Mechanotransduction and YAP-de ...... cancer-associated fibroblasts.

@en

Mechanotransduction and YAP-de ...... cancer-associated fibroblasts.

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prefLabel

Mechanotransduction and YAP-de ...... cancer-associated fibroblasts.

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Mechanotransduction and YAP-de ...... cancer-associated fibroblasts.

@nl

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Nature Cell Biology

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Mechanotransduction and YAP-de ...... cancer-associated fibroblasts

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Kevin Harrington

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Peter Williamson

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Robert P Jenkins

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Shahid I Chaudhry

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Steven Hooper

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P2860

Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition

Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

TEAD mediates YAP-dependent gene induction and growth control

The hippo signaling pathway in development and cancer

Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

Matrix crosslinking forces tumor progression by enhancing integrin signaling

RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein

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637-646

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10.1038/NCB2756

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6

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15

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Guillaume T Charras

Emad Moeendarbary

Araceli Grande-García

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2013-05-26T00:00:00Z

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236939147

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23708000

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Mechanotransduction

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3836234

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