about
Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopyIntravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cellsStochastic Regulation of her1/7 Gene Expression Is the Source of Noise in the Zebrafish Somite Clock Counteracted by Notch SignallingLocalized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motilityConditional ROCK activation in vivo induces tumor cell dissemination and angiogenesisRac activation and inactivation control plasticity of tumor cell movementRegulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysisFibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cellsAn open data ecosystem for cell migration research.Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination.A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion.Deficits in axonal transport precede ALS symptoms in vivo.Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.Cost-benefit analysis of the mechanisms that enable migrating cells to sustain motility upon changes in matrix environments.Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology].Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes.Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.Dendritic cells control fibroblastic reticular network tension and lymph node expansion.Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling.Mechanisms of cancer cell invasion.Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility.Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasisMesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization.Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor DisseminationTumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness.Extrinsic factors can mediate resistance to BRAF inhibition in central nervous system melanoma metastasesIntegrin beta1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivoMelanoma invasion - current knowledge and future directions.Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.Illuminating the metastatic process.Imaging tumor cell movement in vivoA Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasisThe actin cytoskeleton in cancer cell motility.Imaging amoeboid cancer cell motility in vivo.Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Erik Sahai
@ast
Erik Sahai
@en
Erik Sahai
@es
Erik Sahai
@nl
Erik Sahai
@sl
type
label
Erik Sahai
@ast
Erik Sahai
@en
Erik Sahai
@es
Erik Sahai
@nl
Erik Sahai
@sl
prefLabel
Erik Sahai
@ast
Erik Sahai
@en
Erik Sahai
@es
Erik Sahai
@nl
Erik Sahai
@sl
P106
P1153
35551546000
P21
P31
P496
0000-0002-3932-5086