The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.
about
Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assaysA targeted point mutation in thrombomodulin generates viable mice with a prethrombotic stateEndothelial cell control of thrombosisActivated protein C: A regulator of human skin epidermal keratinocyte functionMycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer LesionsEndothelial protein C receptor function in murine and human breast cancer developmentDeficiency of superoxide dismutase impairs protein C activation and enhances susceptibility to experimental thrombosisIdentification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptorMechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C functionOne single mRNA encodes the centrosomal protein CCD41 and the endothelial cell protein C receptor (EPCR)Characterization of protein C receptor expression in monocytesA genome-wide association study of the Protein C anticoagulant pathwayMolecular recognition mechanisms of thrombin.Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor.Dysregulation of the microvasculature in nonlesional non-sun-exposed skin of patients with lupus nephritis.Comparative response of platelet fV and plasma fV to activated protein C and relevance to a model of acute traumatic coagulopathy.Activated protein C promotes breast cancer cell migration through interactions with EPCR and PAR-1.The role of EPCR in the pathogenesis of severe malariaActivated protein C action in inflammationAge-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin.Targeted gene sequencing identifies variants in the protein C and endothelial protein C receptor genes in patients with unprovoked venous thromboembolism.Regulation of the protein C anticoagulant and antiinflammatory pathways.Endothelial cell protein C receptor: a multiliganded and multifunctional receptorDisruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality.Carboxypeptidase U at the interface between coagulation and fibrinolysis.Protein C replacement in severe meningococcemia: rationale and clinical experience.Severe malaria is associated with parasite binding to endothelial protein C receptorRole of proteinase 3 in activation of endothelium.PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells.Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis.Mac-1 directly binds to the endothelial protein C-receptor: a link between the protein C anticoagulant pathway and inflammation?Rab GTPases regulate endothelial cell protein C receptor-mediated endocytosis and trafficking of factor VIIaFactor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection.New mechanisms for vascular control of inflammation mediated by natural anticoagulant proteins.Overexpression of the endothelial protein C receptor is detrimental during pneumonia-derived gram-negative sepsis (Melioidosis).Protein C pathway in sepsis.Proteases display biased agonism at protease-activated receptors: location matters!Current clinical practice. DIC 2002: a review of disseminated intravascular coagulation.Molecular recognition in the protein C anticoagulant pathway.
P2860
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P2860
The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The endothelial cell protein C ...... rombin-thrombomodulin complex.
@en
The endothelial cell protein C ...... rombin-thrombomodulin complex.
@nl
type
label
The endothelial cell protein C ...... rombin-thrombomodulin complex.
@en
The endothelial cell protein C ...... rombin-thrombomodulin complex.
@nl
prefLabel
The endothelial cell protein C ...... rombin-thrombomodulin complex.
@en
The endothelial cell protein C ...... rombin-thrombomodulin complex.
@nl
P2093
P2860
P356
P1476
The endothelial cell protein C ...... hrombin-thrombomodulin complex
@en
P2093
G L Ferrell
J S Mollica
S Kurosawa
P2860
P304
10212-10216
P356
10.1073/PNAS.93.19.10212
P407
P577
1996-09-01T00:00:00Z