Ebola virus VP35 antagonizes PKR activity through its C-terminal interferon inhibitory domain.
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Filoviral immune evasion mechanismsIntracellular events and cell fate in filovirus infectionDRBP76 associates with Ebola virus VP35 and suppresses viral polymerase functionMutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcomeEmerging targets and novel approaches to Ebola virus prophylaxis and treatmentEbola virus RNA editing depends on the primary editing site sequence and an upstream secondary structureEbolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppressionMutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea PigsStructural basis for dsRNA recognition and interferon antagonism by Ebola VP35Structural and Functional Characterization of Reston Ebola Virus VP35 Interferon Inhibitory DomainMarburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon AntagonismStructural basis for Marburg virus VP35-mediated immune evasion mechanismsDevelopment of RNA Aptamers Targeting Ebola Virus VP35In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor ActivityHiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses.How Ebola virus counters the interferon system.Camouflage and misdirection: the full-on assault of ebola virus diseaseMolecular mechanisms of Ebola virus pathogenesis: focus on cell death.Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses.An upstream open reading frame modulates ebola virus polymerase translation and virus replication.Ebolavirus VP35 is a multifunctional virulence factor.Ebolavirus proteins suppress the effects of small interfering RNA by direct interaction with the mammalian RNA interference pathway.Tackling Ebola: new insights into prophylactic and therapeutic intervention strategies.Toll-like receptor-3 is dispensable for the innate microRNA response to West Nile virus (WNV).Evasion of the interferon-mediated antiviral response by filoviruses.The importance of the NP: VP35 ratio in Ebola virus nucleocapsid formationInnate immune evasion by filovirusesDifferent Temporal Effects of Ebola Virus VP35 and VP24 Proteins on Global Gene Expression in Human Dendritic Cells.Assessing the contribution of interferon antagonism to the virulence of West African Ebola virusesImmunological features underlying viral hemorrhagic feversAn Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions.Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells.Predictive and comparative analysis of Ebolavirus proteinsTopoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion.Minigenomes, transcription and replication competent virus-like particles and beyond: reverse genetics systems for filoviruses and other negative stranded hemorrhagic fever virusesEbola virus does not block apoptotic signaling pathways.Ebola virus VP35 induces high-level production of recombinant TPL-2-ABIN-2-NF-κB1 p105 complex in co-transfected HEK-293 cellsThe L-VP35 and L-L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antivirals.Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions.Evasion of interferon responses by Ebola and Marburg viruses.
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Ebola virus VP35 antagonizes PKR activity through its C-terminal interferon inhibitory domain.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 10 June 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Ebola virus VP35 antagonizes P ...... interferon inhibitory domain.
@en
Ebola virus VP35 antagonizes P ...... interferon inhibitory domain.
@nl
type
label
Ebola virus VP35 antagonizes P ...... interferon inhibitory domain.
@en
Ebola virus VP35 antagonizes P ...... interferon inhibitory domain.
@nl
prefLabel
Ebola virus VP35 antagonizes P ...... interferon inhibitory domain.
@en
Ebola virus VP35 antagonizes P ...... interferon inhibitory domain.
@nl
P2860
P356
P1433
P1476
Ebola virus VP35 antagonizes P ...... interferon inhibitory domain.
@en
P2093
Michael Schümann
Thorsten Gantke
P2860
P304
P356
10.1128/JVI.00523-09
P407
P577
2009-06-10T00:00:00Z