Reverse genetic generation of recombinant Zaire Ebola viruses containing disrupted IRF-3 inhibitory domains results in attenuated virus growth in vitro and higher levels of IRF-3 activation without inhibiting viral transcription or replication.
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Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonismFiloviral immune evasion mechanismsMutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcomeEbola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular diseaseCapsid Protein of Eastern Equine Encephalitis Virus Inhibits Host Cell Gene ExpressionEbolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppressionStructure of the Ebola VP35 interferon inhibitory domainMutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea PigsStructural basis for dsRNA recognition and interferon antagonism by Ebola VP35Structural and Functional Characterization of Reston Ebola Virus VP35 Interferon Inhibitory DomainMarburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon AntagonismDevelopment of RNA Aptamers Targeting Ebola Virus VP35In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor ActivityThe Ebola virus VP35 protein is a suppressor of RNA silencing.Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNAInterplay between innate immunity and negative-strand RNA viruses: towards a rational modelHiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses.How Ebola virus counters the interferon system.Therapeutics for filovirus infection: traditional approaches and progress towards in silico drug design.Filovirus replication and transcription.Ebolavirus VP35 is a multifunctional virulence factor.Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus.Evasion of the interferon-mediated antiviral response by filoviruses.The importance of the NP: VP35 ratio in Ebola virus nucleocapsid formationThe role of antigen-presenting cells in filoviral hemorrhagic fever: gaps in current knowledge.Applications of high-throughput genomics to antiviral research: evasion of antiviral responses and activation of inflammation during fulminant RNA virus infection.Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion.The Ebola virus VP35 protein binds viral immunostimulatory and host RNAs identified through deep sequencingInhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virusHIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradationDifferential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins.The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains.Expression, purification, crystallization and preliminary X-ray studies of the Ebola VP35 interferon inhibitory domain.Replication-deficient ebolavirus as a vaccine candidate.Ebola virus VP35 antagonizes PKR activity through its C-terminal interferon inhibitory domain.Evasion of interferon responses by Ebola and Marburg viruses.Viral tricks to grid-lock the type I interferon system.Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein.
P2860
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P2860
Reverse genetic generation of recombinant Zaire Ebola viruses containing disrupted IRF-3 inhibitory domains results in attenuated virus growth in vitro and higher levels of IRF-3 activation without inhibiting viral transcription or replication.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Reverse genetic generation of ...... transcription or replication.
@ast
Reverse genetic generation of ...... transcription or replication.
@en
Reverse genetic generation of ...... transcription or replication.
@nl
type
label
Reverse genetic generation of ...... transcription or replication.
@ast
Reverse genetic generation of ...... transcription or replication.
@en
Reverse genetic generation of ...... transcription or replication.
@nl
prefLabel
Reverse genetic generation of ...... transcription or replication.
@ast
Reverse genetic generation of ...... transcription or replication.
@en
Reverse genetic generation of ...... transcription or replication.
@nl
P2860
P50
P356
P1433
P1476
Reverse genetic generation of ...... transcription or replication.
@en
P2093
Jason E Dover
P2860
P304
P356
10.1128/JVI.00044-06
P407
P577
2006-07-01T00:00:00Z