Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.
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Axon injury induced endoplasmic reticulum stress and neurodegenerationThe PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regenerationCalmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin.Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling.Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions.A Health Threat to Bystanders Living in the Homes of Smokers: How Smoke Toxins Deposited on Surfaces Can Cause Insulin Resistance.Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility.Discovering All Transcriptome Single-Nucleotide Polymorphisms and Scanning for Selection Signatures in Ducks (Anas platyrhynchos).TFEB and TFE3 are novel components of the integrated stress response.PERK regulates Gq protein-coupled intracellular Ca(2+) dynamics in primary cortical neuronsStress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes.Role of the unfolded protein response in β cell compensation and failure during diabetes.Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition.Protein misfolding in the endoplasmic reticulum as a conduit to human disease.Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival.The role of Ca2+ signaling in Parkinson's disease.Calcineurin β protects brain after injury by activating the unfolded protein response.PERK leads a hub dictating pancreatic β cell homoeostasis.PERK and filamin A in actin cytoskeleton remodeling at ER-plasma membrane contact sites.Bariatric Surgery Ameliorates Diabetic Cardiac Dysfunction by Inhibiting ER Stress in a Diabetic Rat Model.Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.Post-Liver Transplantation Diabetes Mellitus: A Review of Relevance and Approach to Treatment.The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.
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Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 10 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Insulin secretion and Ca2+ dyn ...... ) in concert with calcineurin.
@en
Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK
@nl
type
label
Insulin secretion and Ca2+ dyn ...... ) in concert with calcineurin.
@en
Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK
@nl
prefLabel
Insulin secretion and Ca2+ dyn ...... ) in concert with calcineurin.
@en
Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK
@nl
P2093
P2860
P356
P1476
Insulin secretion and Ca2+ dyn ...... 3) in concert with calcineurin
@en
P2093
Barbara C McGrath
Douglas R Cavener
Michael W Roe
P2860
P304
33824-33836
P356
10.1074/JBC.M113.503664
P407
P577
2013-10-10T00:00:00Z