Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.
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Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) using pre-steady-state kineticsSAMHD1 has differential impact on the efficacies of HIV nucleoside reverse transcriptase inhibitors.4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanismsOral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaqueStructural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA)MK-8591 (4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine) Exhibits Potent Activity against HIV-2 Isolates and Drug-Resistant HIV-2 Mutants in Culture.HIV pre-exposure prophylaxis for women and infants prevents vaginal and oral HIV transmission in a preclinical model of HIV infection.Physiological Mg2+ Conditions Significantly Alter the Inhibition of HIV-1 and HIV-2 Reverse Transcriptases by Nucleoside and Non-Nucleoside Inhibitors in Vitro.
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Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 07 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Effects of substitutions at th ...... yl-2-fluoro-2'-deoxyadenosine.
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Effects of substitutions at th ...... yl-2-fluoro-2'-deoxyadenosine.
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Effects of substitutions at th ...... yl-2-fluoro-2'-deoxyadenosine.
@en
Effects of substitutions at th ...... yl-2-fluoro-2'-deoxyadenosine.
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Effects of substitutions at th ...... yl-2-fluoro-2'-deoxyadenosine.
@en
Effects of substitutions at th ...... yl-2-fluoro-2'-deoxyadenosine.
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P2093
P2860
P50
P356
P1476
Effects of substitutions at th ...... yl-2-fluoro-2'-deoxyadenosine.
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Ariel N Hagedorn
Bruno Marchand
Eleftherios Michailidis
Hiroaki Mitsuya
Kamalendra Singh
Maxwell D Leslie
Michael A Parniak
Musetta A Steinbach
Tracy L Fetterly
Victor E Marquez
P2860
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P356
10.1128/AAC.01703-13
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P577
2013-10-07T00:00:00Z