Oral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaque
about
Efficient Inhibition of HIV Replication in the Gastrointestinal and Female Reproductive Tracts of Humanized BLT Mice by EFdAStimulation of Liver X Receptor Has Potent Anti-HIV Effects in a Humanized Mouse Model of HIV Infection.The Nucleoside Analog BMS-986001 Shows Greater In Vitro Activity against HIV-2 than against HIV-1.Inhibition of Heat Shock Protein 90 Prevents HIV ReboundStructural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA)MK-8591 (4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine) Exhibits Potent Activity against HIV-2 Isolates and Drug-Resistant HIV-2 Mutants in Culture.Universal antiretroviral regimens: thinking beyond one-pill-once-a-day.HIV pre-exposure prophylaxis for women and infants prevents vaginal and oral HIV transmission in a preclinical model of HIV infection.Standardization of a cytometric p24-capture bead-assay for the detection of main HIV-1 subtypes.Targeting of CDK9 with indirubin 3'-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice.Physiological Mg2+ Conditions Significantly Alter the Inhibition of HIV-1 and HIV-2 Reverse Transcriptases by Nucleoside and Non-Nucleoside Inhibitors in Vitro.M184I/V substitutions and E138K/M184I/V double substitutions in HIV reverse transcriptase do not significantly affect the antiviral activity of EFdA.Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03.Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy.From in silico hit to long-acting late-stage preclinical candidate to combat HIV-1 infection.HIV replication and latency in a humanized NSG mouse model during suppressive oral combinational ART.Emerging reverse transcriptase inhibitors for HIV-1 infection.Harnessing nanostructured systems for improved treatment and prevention of HIV disease
P2860
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P2860
Oral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaque
description
2015 nî lūn-bûn
@nan
2015 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Oral administration of the nuc ...... in mice and the rhesus macaque
@ast
Oral administration of the nuc ...... in mice and the rhesus macaque
@en
Oral administration of the nucleoside EFdA
@nl
type
label
Oral administration of the nuc ...... in mice and the rhesus macaque
@ast
Oral administration of the nuc ...... in mice and the rhesus macaque
@en
Oral administration of the nucleoside EFdA
@nl
prefLabel
Oral administration of the nuc ...... in mice and the rhesus macaque
@ast
Oral administration of the nuc ...... in mice and the rhesus macaque
@en
Oral administration of the nucleoside EFdA
@nl
P2093
P2860
P356
P1476
Oral administration of the nuc ...... in mice and the rhesus macaque
@en
P2093
Aaron B Reeve
Barbara Sloan
Cheryl A Stoddart
Galina Kosikova
Jose M Rivera
Mary E Moreno
Michael A Parniak
Michael Murphey-Corb
Pheroze Joshi
Sofiya A Galkina
P2860
P304
P356
10.1128/AAC.05036-14
P407
P577
2015-05-04T00:00:00Z