Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones
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Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1 H -isoindole Derivatives, Inhibitors of HIV-1 IntegraseModeling organochlorine compounds and the σ-hole effect using a polarizable multipole force fieldHIV-1 IN inhibitors: 2010 update and perspectivesBicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.New first and second generation inhibitors of human immunodeficiency virus-1 integrase.4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.MK-0536 inhibits HIV-1 integrases resistant to raltegravirMolecular dynamics approaches estimate the binding energy of HIV-1 integrase inhibitors and correlate with in vitro activity.6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality.Progress in HIV-1 Integrase Inhibitors: A Review of their Chemical Structure Diversity.Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants.Synthesis and Anti-HIV-1 Activity Evaluation for Novel 3a,6a-Dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives.
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Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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Examination of halogen substit ...... xy-1H-isoindole-1,3(2H)-diones
@en
Examination of halogen substit ...... y-1H-isoindole-1,3(2H)-diones.
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label
Examination of halogen substit ...... xy-1H-isoindole-1,3(2H)-diones
@en
Examination of halogen substit ...... y-1H-isoindole-1,3(2H)-diones.
@nl
prefLabel
Examination of halogen substit ...... xy-1H-isoindole-1,3(2H)-diones
@en
Examination of halogen substit ...... y-1H-isoindole-1,3(2H)-diones.
@nl
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P2860
P1476
Examination of halogen substit ...... xy-1H-isoindole-1,3(2H)-diones
@en
P2093
B Christie Vu
Christophe Marchand
Kasthuraiah Maddali
Terrence R Burke
Xue Zhi Zhao
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P356
10.1016/J.BMCL.2009.03.122
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2009-03-28T00:00:00Z