Structure-based ligand design and the promise held for antiprotozoan drug discovery.
about
Pseudomonas aeruginosa 4-amino-4-deoxychorismate lyase: spatial conservation of an active site tyrosine and classification of two types of enzymeNematode phospholipid metabolism: an example of closing the genome-structure-function circleStructure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzymeStructure and Reactivity of Bacillus subtilis MenD Catalyzing the First Committed Step in Menaquinone BiosynthesisStructure ofStaphylococcus aureusadenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discoveryHigh-resolution structures ofTrypanosoma bruceipteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug targetStructure of recombinantLeishmania donovanipteridine reductase reveals a disordered active siteCrystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroateStructure ofLeishmania majorcysteine synthaseAcinetobacter baumanniiFolD ligand complexes - potent inhibitors of folate metabolism and a re-evaluation of the structure of LY374571The crystal structure of Leishmania major N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug targetThe AEROPATH project targetingPseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discoveryStructure and Reaction Mechanism of Phosphoethanolamine Methyltransferase from the Malaria Parasite Plasmodium falciparumStructure ofPseudomonas aeruginosainosine 5′-monophosphate dehydrogenaseStructure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase fromAcinetobacter baumanniiAssessment of Pseudomonas aeruginosa N5,N10-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug TargetTwo high-resolution structures of the human E3 ubiquitin ligase Siah1High-resolution structure of the M14-type cytosolic carboxypeptidase fromBurkholderia cenocepaciarefined exploitingPDB_REDOstrategiesIsoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasitesAn alternative mechanism for the methylation of phosphoethanolamine catalyzed by Plasmodium falciparum phosphoethanolamine methyltransferase.Combined docking, molecular dynamics simulations and spectroscopic studies for the rational design of a dipeptide ligand for affinity chromatography separation of human serum albumin.The structure of tubulin-binding cofactor A from Leishmania major infers a mode of association during the early stages of microtubule assemblyThermodynamic Proxies to Compensate for Biases in Drug Discovery Methods.The eradication of leprosy: molecular modeling techniques for novel drug discovery.Open and compressed conformations of Francisella tularensis ClpP.An Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain-Acivicin Complex.Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode Haemonchus contortus.The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design.Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the
P2860
Q21135242-B055E7AE-ED4D-49FB-920C-3CAF2107A2CDQ26853143-62E0CFFC-9F63-413A-97EB-0D08AF1164A7Q27658837-3D022EDB-CE7A-40B8-AD1F-413A3250CEBCQ27663058-ED8BC2E9-B970-4659-B5D3-8B7CA14F12E2Q27663932-AE6BF2DC-0BDA-4228-8D5A-9F53046E1F05Q27666140-0D768126-D909-4869-BE1F-C3B8F6845B19Q27666482-61E7E5ED-110E-411F-8D70-67E6E40EBDD1Q27667765-7F5A1844-5822-4D45-93AF-69051E5B1AC2Q27670578-9E7736F1-9F6D-49E6-8099-B006EB9E9212Q27674388-81DED251-A0FA-4BB3-BBA5-DFC4B07255CAQ27675760-C190F771-3D6C-446D-A244-8579110989FFQ27675787-1C180828-BC4D-4162-873D-B8641242087EQ27675800-D476FF48-17EB-48EE-B36A-4613F87DB05DQ27676976-E4D34760-85B9-4A7F-82F3-52F454611189Q27678406-DDBC1F01-840E-43F5-890D-6BCC2982DA9FQ27678891-0314D00F-D148-402C-991C-E1A370D4F486Q27680823-D39916B0-5D43-4ED1-8C82-C0E78C47FC50Q27681751-6A5EDC1D-78B9-4127-8E8F-D0EB61DCDC1CQ28727252-5D4D5549-D4CD-4D73-97FD-E478D7583694Q30367523-28BBA4C6-764A-4DC9-B70B-E5D75F298A01Q35252046-61918F5A-8930-4D2D-9CDC-B6537CA77FA9Q35592532-B3B37255-AE38-4ECC-ADEA-2A4518550C66Q35756877-2C197F4C-5136-4739-8B62-A4A21229EF29Q38127263-A4C8AD39-CE87-4C61-A49C-7B5DEF60017EQ38801229-ACEDDA55-7A04-4F03-80E0-CE56917076FBQ38883627-3F433CE9-4F32-475A-A06D-DC489A829263Q38928123-BF88FD23-608C-497E-99C2-8AF458AEA7CDQ47345749-654E578B-C2AB-4784-BD2C-2F9855AC2821Q58853482-FFE823CC-790D-4AE0-A6D9-5E544649FEA3
P2860
Structure-based ligand design and the promise held for antiprotozoan drug discovery.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 22 December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Structure-based ligand design and the promise held for antiprotozoan drug discovery.
@en
Structure-based ligand design and the promise held for antiprotozoan drug discovery.
@nl
type
label
Structure-based ligand design and the promise held for antiprotozoan drug discovery.
@en
Structure-based ligand design and the promise held for antiprotozoan drug discovery.
@nl
prefLabel
Structure-based ligand design and the promise held for antiprotozoan drug discovery.
@en
Structure-based ligand design and the promise held for antiprotozoan drug discovery.
@nl
P2860
P921
P356
P1476
Structure-based ligand design and the promise held for antiprotozoan drug discovery
@en
P2093
William N Hunter
P2860
P304
11749-11753
P356
10.1074/JBC.R800072200
P407
P50
P5008
P577
2008-12-22T00:00:00Z