Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. - Wikidata - wikimedia - TriplyDB

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.

http://www.wikidata.org/entity/Q37357625

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SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.Modeling Alzheimer's Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns Genes associated with Alzheimer's disease: an overview and current status Toward precision medicine in Alzheimer's disease β-Amyloid: the key peptide in the pathogenesis of Alzheimer's disease Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities Additional mechanisms conferring genetic susceptibility to Alzheimer's disease Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families Clinical genetics of Alzheimer's disease Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer disease.ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function Genetics and biology of Alzheimer's disease and frontotemporal lobar degeneration The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE.Identification of rare variants in Alzheimer's disease.Alzheimer's disease risk genes and mechanisms of disease pathogenesis Exploiting protein-protein interaction networks for genome-wide disease-gene prioritization An association study on ADAM10 promoter polymorphisms and atherosclerotic cerebral infarction in a Chinese population.Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease Apomorphine and Alzheimer Aβ: roles for regulated α cleavage, autophagy, and antioxidation?Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system.An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis.Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain.Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors.Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci.ADAM10 expression and promoter haplotype in Alzheimer's disease.Chaperone-like effect of the linker on the isolated C-terminal domain of rabbit muscle creatine kinase.Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease.The IgLON Family Member Negr1 Promotes Neuronal Arborization Acting as Soluble Factor via FGFR2.Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation.Fluorescent Analogue of Batimastat Enables Imaging of α-Secretase in Living Cells Modeling Alzheimer's disease: from past to future Promoter Variants of the ADAM10 Gene and Their Roles in Temporal Lobe Epilepsy.The ADAMs family of proteases as targets for the treatment of cancer.Alzheimer's disease genetics: from the bench to the clinic.Genetics and underlying pathology of dementia.The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer's Disease.An Overview of Genome-Wide Association Studies in Alzheimer's Disease Novel susceptibility loci for Alzheimer's disease.Monoaminergic neuropathology in Alzheimer's disease.Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease.

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Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.

http://www.wikidata.org/entity/Q37357625

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 15 July 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Potential late-onset Alzheimer ...... te {alpha}-secretase activity.

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Potential late-onset Alzheimer ...... te {alpha}-secretase activity.

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Potential late-onset Alzheimer ...... te {alpha}-secretase activity.

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Potential late-onset Alzheimer ...... te {alpha}-secretase activity.

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Potential late-onset Alzheimer ...... te {alpha}-secretase activity.

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Potential late-onset Alzheimer ...... te {alpha}-secretase activity.

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Human Molecular Genetics

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Potential late-onset Alzheimer ...... te {alpha}-secretase activity.

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Basavaraj Hooli

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David Norton

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Donna Romano

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Giuseppina Tesco

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Jaehong Suh

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K David Becker

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Kathy Elliott

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Kristina Mullin

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Mimy H Truong

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Minji Kim

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P2860

Reliability and Validity of NINCDS-ADRDA Criteria for Alzheimer's Disease

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family

Assessment of Alzheimer's disease case-control associations using family-based methods

[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

Family-based association between Alzheimer's disease and variants in UBQLN1

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

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3987-3996

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scholarly article

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10.1093/HMG/DDP323

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20

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18

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Rudolph E. Tanzi

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2009-07-15T00:00:00Z

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26676375

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19608551

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Alzheimer's disease

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2748890

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