The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation.
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Structure and functionality in flavivirus NS-proteins: perspectives for drug designThe modeled structure of the RNA dependent RNA polymerase of GBV-C virus suggests a role for motif E in Flaviviridae RNA polymerases.Using the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and DynamicsMutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymeraseA novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.Recombinant viral RdRps can initiate RNA synthesis from circular templates.Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C VirusThe NS5A Protein of Bovine Viral Diarrhea Virus Contains an Essential Zinc-Binding Site Similar to That of the Hepatitis C Virus NS5A ProteinGeneral Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide AnaloguesStructure and Function of Flavivirus NS5 MethyltransferaseCrystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom ResolutionIdentification of Residues Critical for the Interferon Antagonist Function of Langat Virus NS5 Reveals a Role for the RNA-Dependent RNA Polymerase DomainStabilization of Poliovirus Polymerase by NTP Binding and Fingers–Thumb InteractionsThe Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral ReplicationDesign, expression, and purification of a Flaviviridae polymerase using a high-throughput approach to facilitate crystal structure determinationStructure-function relationships among RNA-dependent RNA polymerasesA Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus PolymeraseNontemplated Terminal Nucleotidyltransferase Activity of Double-Stranded RNA Bacteriophage 6 RNA-Dependent RNA Polymerase1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside InhibitorsInhibition of Sphingosine Kinase by Bovine Viral Diarrhea Virus NS3 Is Crucial for Efficient Viral Replication and CytopathogenesisBluetongue virus: dissection of the polymerase complexThe flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structureThe Structure of an RNAi Polymerase Links RNA Silencing and TranscriptionCrystal Structure of Poliovirus 3CD Protein: Virally Encoded Protease and Precursor to the RNA-Dependent RNA PolymeraseThe structure of a birnavirus polymerase reveals a distinct active site topologyStructural insights into mechanisms of catalysis and inhibition in Norwalk virus polymeraseFurther Insights into the Roles of GTP and the C Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA SynthesisA Comprehensive Structure-Function Comparison of Hepatitis C Virus Strain JFH1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture across GenotypesStructure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNACrystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interfaceRNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation stateDistinct Conformations of a Putative Translocation Element in Poliovirus PolymeraseThe FDA-approved drug sofosbuvir inhibits Zika virus infectionStability of the resistance to the thiosemicarbazone derived from 5,6-dimethoxy-1-indanone, a non-nucleoside polymerase inhibitor of bovine viral diarrhea virusThe Structure of the RNA-Dependent RNA Polymerase of a Permutotetravirus Suggests a Link between Primer-Dependent and Primer-Independent PolymerasesPerturbation in the conserved methyltransferase-polymerase interface of flavivirus NS5 differentially affects polymerase initiation and elongationStructure and function of the Zika virus full-length NS5 proteinInfectious DNAs derived from insect-specific flavivirus genomes enable identification of pre- and post-entry host restrictions in vertebrate cellsMechanisms of activity and inhibition of the hepatitis C virus RNA-dependent RNA polymerase.Space constrained homology modelling: the paradigm of the RNA-dependent RNA polymerase of dengue (type II) virus.
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The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 19 March 2004
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The structure of the RNA-depen ...... of GTP in de novo initiation.
@en
The structure of the RNA-depen ...... of GTP in de novo initiation.
@nl
type
label
The structure of the RNA-depen ...... of GTP in de novo initiation.
@en
The structure of the RNA-depen ...... of GTP in de novo initiation.
@nl
prefLabel
The structure of the RNA-depen ...... of GTP in de novo initiation.
@en
The structure of the RNA-depen ...... of GTP in de novo initiation.
@nl
P2093
P2860
P356
P1476
The structure of the RNA-depen ...... of GTP in de novo initiation.
@en
P2093
Daniel C Pevear
Dorothy C Young
James M Groarke
Janet L Smith
Kyung H Choi
P2860
P304
P356
10.1073/PNAS.0400660101
P407
P577
2004-03-19T00:00:00Z