Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A.
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The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin AClostridial glucosylating toxins enter cells via clathrin-mediated endocytosisClostridium difficile toxins: mechanism of action and role in disease.Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and BClostridium difficile infection: molecular pathogenesis and novel therapeuticsMechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray CrystallographyGeneration of stable lipid raft microdomains in the enterocyte brush border by selective endocytic removal of non-raft membraneIn vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and toxin BEscherichia coli strain RDEC-1 AF/R1 endogenous fimbrial glycoconjugate receptor molecules in rabbit small intestineExpression of recombinant Clostridium difficile toxin A and B in Bacillus megateriumLRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxinsMicrobes and microbial toxins: paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxins.Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A.Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation.Glucosyltransferases of viridans group streptococci modulate interleukin-6 and adhesion molecule expression in endothelial cells and augment monocytic cell adherence.Theodore E. Woodward Award. How bacterial enterotoxins work: insights from in vivo studies.Upregulation of the host SLC11A1 gene by Clostridium difficile toxin B facilitates glucosylation of Rho GTPases and enhances toxin lethality.Cytokeratin 8 is an epithelial cell receptor for Pet, a cytotoxic serine protease autotransporter of Enterobacteriaceae.The insect peptide coprisin prevents Clostridium difficile-mediated acute inflammation and mucosal damage through selective antimicrobial activity.Human Clostridium difficile infection: altered mucus production and composition.Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity.Toward a structural understanding of Clostridium difficile toxins A and B.Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent EndocytosisThe comparative pathology of Clostridium difficile-associated disease.C-terminal repeats of Clostridium difficile toxin A induce production of chemokine and adhesion molecules in endothelial cells and promote migration of leukocytesThinking beyond the colon-small bowel involvement in clostridium difficile infection.Antibody-enhanced, Fc gamma receptor-mediated endocytosis of Clostridium difficile toxin ANeurokinin-1 (NK-1) receptor is required in Clostridium difficile- induced enteritisAnti-glycosyl antibodies in lipid rafts of the enterocyte brush border: a possible host defense against pathogens.Clostridium difficile toxins A and B: Receptors, pores, and translocation into cells.Acylation of Escherichia coli hemolysin: a unique protein lipidation mechanism underlying toxin function.Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B.gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A.Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages.Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK.Clostridium difficile toxin A carboxyl-terminus peptide lacking ADP-ribosyltransferase activity acts as a mucosal adjuvant.The attachment, internalization, and time-dependent, intracellular distribution of Clostridium difficile toxin A in porcine intestinal explants.Evidence for dual receptor-binding sites in Clostridium difficile toxin A.The role of toxins in Clostridium difficile infection.A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins.
P2860
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P2860
Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Rabbit sucrase-isomaltase cont ...... Clostridium difficile toxin A.
@en
Rabbit sucrase-isomaltase cont ...... Clostridium difficile toxin A.
@nl
type
label
Rabbit sucrase-isomaltase cont ...... Clostridium difficile toxin A.
@en
Rabbit sucrase-isomaltase cont ...... Clostridium difficile toxin A.
@nl
prefLabel
Rabbit sucrase-isomaltase cont ...... Clostridium difficile toxin A.
@en
Rabbit sucrase-isomaltase cont ...... Clostridium difficile toxin A.
@nl
P2093
P2860
P356
P1476
Rabbit sucrase-isomaltase cont ...... Clostridium difficile toxin A.
@en
P2093
C Cladaras
C Pothoulakis
I Castagliuolo
J Linevsky
J S Montcrief
J T LaMont
R J Gilbert
P2860
P304
P356
10.1172/JCI118835
P407
P577
1996-08-01T00:00:00Z