Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.
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Revealing the genetic basis of multiple sclerosis: are we there yet?Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunityGenome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility lociAutoimmune diseases - connecting risk alleles with molecular traits of the immune system.A functional framework for interpretation of genetic associations in T1DLow-dose interleukin-2 therapy: a driver of an imbalance between immune tolerance and autoimmunityTherapeutic efficacy of monthly subcutaneous injection of daclizumab in relapsing multiple sclerosisCellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lociGenetics and epigenetics of rheumatoid arthritisRegulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding TrialProtocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive studyGeneration of primary human intestinal T cell transcriptomes reveals differential expression at genetic risk loci for immune-mediated diseaseThe role of genetics in the etiology of schizophreniaNetwork biology concepts in complex disease comorbiditiesIdentification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene ExpressionPlasma Levels of Soluble Interleukin-2 Receptor α: Associations With Clinical Cardiovascular Events and Genome-Wide Association Scan.Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine MappingFine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.Negligible impact of rare autoimmune-locus coding-region variants on missing heritabilityFunctional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseasesConfirmation of novel type 1 diabetes risk loci in families.Genetics of type 1 diabetes: what's next?Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseasesFluorescence intensity normalisation: correcting for time effects in large-scale flow cytometric analysis.Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis.Multiplexed immunophenotyping of human antigen-presenting cells in whole blood by polychromatic flow cytometry.Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial.Autoimmune polyendocrine syndromes: clues to type 1 diabetes pathogenesis.Identifying genetic loci and spleen gene coexpression networks underlying immunophenotypes in BXD recombinant inbred miceLeveraging human genetics to develop future therapeutic strategies in rheumatoid arthritisGenetics and epigenetics of the skin meet deep sequence.Recent advances in the genetics of systemic lupus erythematosus.Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets.Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes.Blood pressure and human genetic variation in the general population.Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.Proteome-wide analysis of disease-associated SNPs that show allele-specific transcription factor binding.An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells.
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Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 August 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Cell-specific protein phenotyp ...... -selectable human bioresource.
@en
Cell-specific protein phenotyp ...... -selectable human bioresource.
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type
label
Cell-specific protein phenotyp ...... -selectable human bioresource.
@en
Cell-specific protein phenotyp ...... -selectable human bioresource.
@nl
prefLabel
Cell-specific protein phenotyp ...... -selectable human bioresource.
@en
Cell-specific protein phenotyp ...... -selectable human bioresource.
@nl
P2093
P2860
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Cell-specific protein phenotyp ...... -selectable human bioresource.
@en
P2093
Barry Healy
Gillian Coleman
Jason D Cooper
Jennie H M Yang
Kate Downes
Kerstin Koch
Linda S Wicker
Matthew Himsworth
Sarah Nutland
P2860
P2888
P304
P356
10.1038/NG.434
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P50
P577
2009-08-23T00:00:00Z
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P6179
1016741965