Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.
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The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid basesCeramide: a common pathway for atherosclerosis?Further evaluation of plasma sphingomyelin levels as a risk factor for coronary artery diseaseSphingolipids in High Fat Diet and Obesity-Related DiseasesElectronegative LDL: a circulating modified LDL with a role in inflammationFrom Molecules to the Clinic: Linking Schizophrenia and Metabolic Syndrome through Sphingolipids MetabolismRole of ceramide in diabetes mellitus: evidence and mechanisms.Association of plasma sphingomyelin levels and incident coronary heart disease events in an adult population: Multi-Ethnic Study of AtherosclerosisSelective reduction in the sphingomyelin content of atherogenic lipoproteins inhibits their retention in murine aortas and the subsequent development of atherosclerosis.The yins and yangs of ceramide.Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitroOxidized LDL: diversity, patterns of recognition, and pathophysiology.Modified LDL - trigger of atherosclerosis and inflammation in the arterial intima.Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A2 group V and secretory sphingomyelinase.Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis.Infection and inflammation-induced proatherogenic changes of lipoproteins.Lactosylceramide causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells.Aggregation and fusion of low-density lipoproteins in vivo and in vitro.Impact of sphingomyelin levels on coronary heart disease and left ventricular systolic function in humans.Ceramide mediates Ox-LDL-induced human vascular smooth muscle cell calcification via p38 mitogen-activated protein kinase signalingApolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregationCharacterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr-/- mice fed on a high-fat dietTargeted Lipidomic and Transcriptomic Analysis Identifies Dysregulated Renal Ceramide Metabolism in a Mouse Model of Diabetic Kidney DiseaseSphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism.Sphingolipid metabolism and obesity-induced inflammation.Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progressionSize-selective uptake of colloidal low density lipoprotein aggregates by cultured white blood cellsApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycan.Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase.Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in miceLiver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels.Roles and regulation of secretory and lysosomal acid sphingomyelinase.Endogenous ceramide contributes to the transcytosis of oxLDL across endothelial cells and promotes its subendothelial retention in vascular wall.Acidification of the intimal fluid: the perfect storm for atherogenesisPlasma Lipidome Analysis by Liquid Chromatography-High Resolution Mass Spectrometry and Ion Mobility of Hypertriglyceridemic Patients on Extended-Release Nicotinic Acid: a Pilot Study.Inflammatory processes in cardiovascular disease: a route to targeted therapies.Lipid Biomarkers for Risk Assessment in Acute Coronary Syndromes.Sphingolipids and Lipoproteins in Health and Metabolic Disorders.Ceramide in lipid particles enhances heparan sulfate proteoglycan and low density lipoprotein receptor-related protein-mediated uptake by macrophages.Uptake and metabolism of low density lipoproteins with elevated ceramide content by human microvascular endothelial cells: implications for the regulation of apoptosis.
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Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Rabbit aorta and human atheros ...... n of atherogenic lipoproteins.
@en
Rabbit aorta and human atheros ...... n of atherogenic lipoproteins.
@nl
type
label
Rabbit aorta and human atheros ...... n of atherogenic lipoproteins.
@en
Rabbit aorta and human atheros ...... n of atherogenic lipoproteins.
@nl
prefLabel
Rabbit aorta and human atheros ...... n of atherogenic lipoproteins.
@en
Rabbit aorta and human atheros ...... n of atherogenic lipoproteins.
@nl
P2093
P2860
P921
P356
P1476
Rabbit aorta and human atheros ...... on of atherogenic lipoproteins
@en
P2093
J Tweedie-Hardman
S L Schissel
P2860
P304
P356
10.1172/JCI118934
P407
P577
1996-09-01T00:00:00Z