Hepatic origin of cholesteryl oleate in coronary artery atherosclerosis in African green monkeys. Enrichment by dietary monounsaturated fat.
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ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membraneSaturated fat, carbohydrate, and cardiovascular diseaseCholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulationIdentification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates.Dietary n-3 LCPUFA from fish oil but not alpha-linolenic acid-derived LCPUFA confers atheroprotection in mice.Impact of dietary fat type within the context of altered cholesterol homeostasis on cholesterol and lipoprotein metabolism in the F1B hamster.Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, miceDietary monounsaturated fatty acids appear not to provide cardioprotectionACAT2 stimulates cholesteryl ester secretion in apoB-containing lipoproteins.Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discoveryHigh-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humansTissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood.PRD125, a potent and selective inhibitor of sterol O-acyltransferase 2 markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient miceCholesteryl esters associated with acyl-CoA:cholesterol acyltransferase predict coronary artery disease in patients with symptoms of acute coronary syndrome.LDL cholesteryl oleate as a predictor for atherosclerosis: evidence from human and animal studies on dietary fatInhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosisEstrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in monkeys.The Demographic and Adaptive History of the African Green Monkey.Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol lossEffects of dietary palmitoleic acid on plasma lipoprotein profile and aortic cholesterol accumulation are similar to those of other unsaturated fatty acids in the F1B golden Syrian hamster.Reply to JS WhiteLecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice.Primates highly responsive to dietary cholesterol up-regulate hepatic ACAT2, and less responsive primates do not.Fatty acids differentially regulate hepatic cholesteryl ester formation and incorporation into lipoproteins in the liver of the mouse.Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption.Hepatic acyl-coenzyme a:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia.ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice.
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Hepatic origin of cholesteryl oleate in coronary artery atherosclerosis in African green monkeys. Enrichment by dietary monounsaturated fat.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1997
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Hepatic origin of cholesteryl ...... y dietary monounsaturated fat.
@en
Hepatic origin of cholesteryl ...... y dietary monounsaturated fat.
@nl
type
label
Hepatic origin of cholesteryl ...... y dietary monounsaturated fat.
@en
Hepatic origin of cholesteryl ...... y dietary monounsaturated fat.
@nl
prefLabel
Hepatic origin of cholesteryl ...... y dietary monounsaturated fat.
@en
Hepatic origin of cholesteryl ...... y dietary monounsaturated fat.
@nl
P2093
P2860
P356
P1476
Hepatic origin of cholesteryl ...... y dietary monounsaturated fat.
@en
P2093
P2860
P356
10.1172/JCI119524
P407
P577
1997-07-01T00:00:00Z