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Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activityFocus on molecules: heparanase.Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to HyperpermeabilitySyndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and PrognosticationHeparan sulfate in skeletal development, growth, and pathology: the case of hereditary multiple exostosesInvolvement of heparanase in atherosclerosis and other vessel wall pathologiesNephroprotective effect of heparanase in experimental nephrotic syndromeImpact of heparanase on renal fibrosisMechanisms of heparanase inhibitors in cancer therapy.A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis.Expression of heparanase in soft tissue sarcomas of adults.Regulation of intracellular signaling by extracellular glycan remodeling.Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti Angiogenic AgentGenetic variations in the heparanase gene (HPSE) associate with increased risk of GVHD following allogeneic stem cell transplantation: effect of discrepancy between recipients and donorsA novel human heparanase splice variant, T5, endowed with protumorigenic characteristics.Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis.Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levelsModulation of syndecan-1 shedding after hemorrhagic shock and resuscitation.Oligosaccharide substrate preferences of human extracellular sulfatase Sulf2 using liquid chromatography-mass spectrometry based glycomics approaches.Heparanase cooperates with Ras to drive breast and skin tumorigenesisTumorigenic and adhesive properties of heparanase.Essential roles for soluble virion-associated heparan sulfonated proteoglycans and growth factors in human papillomavirus infections.Heparanase enhances local and systemic osteolysis in multiple myeloma by upregulating the expression and secretion of RANKLHeparanase enhances myeloma progression via CXCL10 downregulation.Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and α-actinin.Clinical significance of heparanase splice variant (t5) in renal cell carcinoma: evaluation by a novel t5-specific monoclonal antibodyDevelopment of a biosensor for detection of pleural mesothelioma cancer biomarker using surface imprintingPre-clinical and clinical significance of heparanase in Ewing's sarcoma.Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activityPlasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock.Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancerTumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesis.Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotypeUrinary tract effects of HPSE2 mutations.Protease Activity and the Role of the Endothelial Glycocalyx in Inflammation.Shed syndecan-2 enhances tumorigenic activities of colon cancer cells.Placental accommodations for transport and metabolism during intra-uterine crowding in pigsShedding of the endothelial glycocalyx in arterioles, capillaries, and venules and its effect on capillary hemodynamics during inflammation.Heparanase and syndecan-1 interplay orchestrates fibroblast growth factor-2-induced epithelial-mesenchymal transition in renal tubular cells.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 03 September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Heparanase: busy at the cell surface.
@en
Heparanase: busy at the cell surface.
@nl
type
label
Heparanase: busy at the cell surface.
@en
Heparanase: busy at the cell surface.
@nl
prefLabel
Heparanase: busy at the cell surface.
@en
Heparanase: busy at the cell surface.
@nl
P2093
P2860
P1476
Heparanase: busy at the cell surface.
@en
P2093
Israel Vlodavsky
Ralph D Sanderson
P2860
P304
P356
10.1016/J.TIBS.2009.06.005
P577
2009-09-03T00:00:00Z