Identification of an additional negative regulatory region for p53 sequence-specific DNA binding
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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcriptionPeptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cellsAn induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificityp53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damageA peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutantsChk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequencesp53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300Chondroitin Sulfate as a Molecular Portal That Preferentially Mediates the Apoptotic Killing of Tumor Cells by Penetratin-directed Mitochondria-disrupting Peptidesp53 Amino-terminus region (1-125) stabilizes and restores heat denatured p53 wild phenotype.USP7/HAUSP promotes the sequence-specific DNA binding activity of p53.Definition of the p53 functional domains necessary for inducing apoptosis.Comparison of the protein-protein interfaces in the p53-DNA crystal structures: towards elucidation of the biological interface.Core domain interactions in full-length p53 in solutionA single-molecule characterization of p53 search on DNAAlanine and proline content modulate global sensitivity to discrete perturbations in disordered proteins.Does p53 affect organismal aging?Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.The complex interactions of p53 with target DNA: we learn as we go.Negative regulation-resistant p53 variant enhances oncolytic adenoviral gene therapy.Dancing on DNA: kinetic aspects of search processes on DNAReactivation of mutant p53: molecular mechanisms and therapeutic potential.Structure and promoter characterization of aldo-keto reductase family 1 B10 gene.Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer.Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability.The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity.Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.Three assays show differences in binding of wild-type and mutant p53 to unique gene sequences.NAD+ modulates p53 DNA binding specificity and function.Evidence for a distinct inhibitory factor in the regulation of p53 functional activity.p53 Latency. C-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences.Temperature effects on the hydrodynamic radius of the intrinsically disordered N-terminal region of the p53 protein.Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.ArhGAP30 promotes p53 acetylation and function in colorectal cancer.Cellular localization of human p53 expressed in the yeast Saccharomyces cerevisiae: effect of NLSI deletion.
P2860
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P2860
Identification of an additional negative regulatory region for p53 sequence-specific DNA binding
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 1998
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Identification of an additiona ...... sequence-specific DNA binding
@en
Identification of an additiona ...... sequence-specific DNA binding.
@nl
type
label
Identification of an additiona ...... sequence-specific DNA binding
@en
Identification of an additiona ...... sequence-specific DNA binding.
@nl
prefLabel
Identification of an additiona ...... sequence-specific DNA binding
@en
Identification of an additiona ...... sequence-specific DNA binding.
@nl
P2093
P2860
P356
P1476
Identification of an additiona ...... sequence-specific DNA binding
@en
P2093
Halazonetis TD
Müller-Tiemann BF
P2860
P304
P356
10.1073/PNAS.95.11.6079
P407
P577
1998-05-01T00:00:00Z