Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage lambda transgene target.
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Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6Genetic instability of cancer cells is proportional to their degree of aneuploidyGATA-3 links tumor differentiation and dissemination in a luminal breast cancer modelA germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformationMutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshiftsTransgenic rat models for mutagenesis and carcinogenesisAnalysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model.Error-free replicative bypass of (6-4) photoproducts by DNA polymerase zeta in mouse and human cellsExpression of hepatitis B virus X protein does not alter the accumulation of spontaneous mutations in transgenic miceModeling variation in tumors in vivoIsolated spermatozoa as indicators of mutations transmitted to progenyCan carcinogenic potency be predicted from in vivo genotoxicity data?: a meta-analysis of historical data.Wavelength dependence of ultraviolet radiation-induced DNA damage as determined by laser irradiation suggests that cyclobutane pyrimidine dimers are the principal DNA lesions produced by terrestrial sunlight.In Vitro Study of Mutagenesis Induced by Crocidolite-Exposed Alveolar Macrophages NR8383 in Cocultured Big Blue Rat2 Embryonic Fibroblasts.Escherichia coli DNA polymerase IV mutator activity: genetic requirements and mutational specificity.Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis.Mutations associated with base excision repair deficiency and methylation-induced genotoxic stressThe phage lambda CII transcriptional activator carries a C-terminal domain signaling for rapid proteolysis.Origin of metastases: subspecies of cancers generated by intrinsic karyotypic variations.Encephalitozoon intestinalis infection increases host cell mutation frequency.Just how does the cII selection system work in Muta Mouse?Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x proteinDNA polymerase beta and mammalian base excision repair.Detection of mutations in transgenic fish carrying a bacteriophage lambda cII transgene targetExplaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy.Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells.Mutagenicity of ultraviolet A radiation in the lacI transgene in Big Blue mouse embryonic fibroblastsInferring somatic mutation rates using the stop-enhanced green fluorescent protein mouseTumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability.The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells.Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.S-nitrosoglutathione reductase deficiency increases mutagenesis from alkylation in mouse liverMechanisms underlying the varied mammary carcinogenicity of the environmental pollutant 6-nitrochrysene and its metabolites (-)-[R,R]- and (+)-[S,S]-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene in the rat.Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations.Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide.Rapid repair of UVA-induced oxidized purines and persistence of UVB-induced dipyrimidine lesions determine the mutagenicity of sunlight in mouse cellsIn vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure.DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice.Highly error-free role of DNA polymerase eta in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cells.Mechanisms of lung tumorigenesis by ethyl carbamate and vinyl carbamate.
P2860
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P2860
Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage lambda transgene target.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Analysis of genetic instabilit ...... phage lambda transgene target.
@en
Analysis of genetic instabilit ...... phage lambda transgene target.
@nl
type
label
Analysis of genetic instabilit ...... phage lambda transgene target.
@en
Analysis of genetic instabilit ...... phage lambda transgene target.
@nl
prefLabel
Analysis of genetic instabilit ...... phage lambda transgene target.
@en
Analysis of genetic instabilit ...... phage lambda transgene target.
@nl
P2093
P2860
P356
P1476
Analysis of genetic instabilit ...... phage lambda transgene target.
@en
P2093
Jakubczak JL
P2860
P304
P356
10.1073/PNAS.93.17.9073
P407
P577
1996-08-01T00:00:00Z